Rejection by Syngeneic Mice of Cell Variants Obtained by Mutagenesis of a Malignant Teratocarcinoma Cell Line

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1977 Jan 1

PMID 264681

Citations 55

Authors

T Boon

O Kellermann

Affiliations

Soon will be listed here.

Abstract

Cells from the malignant teratocarcinoma line PCC4.azal were treated with the mutagen N-methyl-N'-nitro-N-nitrosoguanidine. Fifty-five clones were isolated from the surviving cells. Twelve clones are unable to form tumors in the syngeneic 129/Sv mice. However, these "tum-" clones form tumors as readily as the original cells when they are injected into irradiated mice. Moreover, they stimulate the production of immune memory cells, which protect the injected animals and confer resistance by adoptive transfer. The tum- clones are therefore unable to generate tumors in syngeneic mice because they elicit an immune rejection response.

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