Adrenergic Ligands That Block Oviposition in the Cattle Tick Rhipicephalus Microplus Affect Ovary Contraction

Overview

Journal Sci Rep

Specialty Science

Date 2015 Oct 13

PMID 26456007

Citations 5

Authors

Raquel Cossio-Bayugar

Estefan Miranda-Miranda

Manuel Fernandez-Rubalcaba

Veronica Narvaez Padilla

Enrique Reynaud

Affiliations

Soon will be listed here.

Abstract

The tyraminergic/octopaminergic system is central for the control of arthropod oviposition. Previous works demonstrated that the pharmacological perturbation of this system inhibits oviposition in the cattle tick Rhipicephalus microplus. In this work, we describe a physiologically active whole-mount preparation of the contractile tick ovary that allows the quantitative videometrical analysis of ovary contraction in response to different compounds. Eight adrenergic ligands known to inhibit oviposition, including octopamine and tyramine were tested. These compounds exhibited antagonistic effects; octopamine relaxes the ovary preparation while tyramine induces a very strong contraction. The other adrenergic compounds tested were classified as able to contract or relax ovary muscle tissue. Isoprotenerol has a stronger relaxative effect than octopamine. Tyramine induces the biggest contraction observed of all the compounds tested, followed, in descending amount of contraction, by salbutamol, prazosin, epinastine, clonidine and the acaricide amitraz. The effect of these adrenergic ligands on the ovary preparation, explains why these molecules inhibit tick oviposition and suggest a regulatory mechanism for ovary contraction and relaxation during oviposition. Our results also provide a physiological explanation of the egg-laying inhibition effect of amitraz when used on the cattle tick.

Citing Articles

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Physiological evidence that three known mutations in the para-sodium channel gene confer cypermethrin knockdown resistance in Rhipicephalus microplus.

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Acaricidal effect of Schinus molle (Anacardiaceae) essential oil on unengorged larvae and engorged adult females of Rhipicephalus sanguineus (Acari: Ixodidae).

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Pyrethroid Acaricide Resistance Is Proportional to P-450 Cytochrome Oxidase Expression in the Cattle Tick .

Cossio-Bayugar R, Martinez-Ibanez F, Aguilar-Diaz H, Miranda-Miranda E Biomed Res Int. 2018; 2018:8292465.

PMID: 30069481 PMC: 6057400. DOI: 10.1155/2018/8292465.

References

Lee H, Seong C, Kim Y, Davis R, Han K . Octopamine receptor OAMB is required for ovulation in Drosophila melanogaster. Dev Biol. 2003; 264(1):179-90. DOI: 10.1016/j.ydbio.2003.07.018. View

Gainetdinov R, Premont R, Bohn L, Lefkowitz R, Caron M . Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci. 2004; 27:107-44. DOI: 10.1146/annurev.neuro.27.070203.144206. View

Sjosward K, Hmani M, Davidsson A, Soderkvist P, Schmekel B . Single-isomer R-salbutamol is not superior to racemate regarding protection for bronchial hyperresponsiveness. Respir Med. 2004; 98(10):990-9. DOI: 10.1016/j.rmed.2004.03.005. View

Jan L, Jan Y . Properties of the larval neuromuscular junction in Drosophila melanogaster. J Physiol. 1976; 262(1):189-214. PMC: 1307637. DOI: 10.1113/jphysiol.1976.sp011592. View

Webb R, BOHR D . Relaxation of vascular smooth muscle by isoproterenol, dibutyryl-cyclic AMP and theophylline. J Pharmacol Exp Ther. 1981; 217(1):26-35. View

Roeder T . Tyramine and octopamine: ruling behavior and metabolism. Annu Rev Entomol. 2004; 50:447-77. DOI: 10.1146/annurev.ento.50.071803.130404. View

Maqueira B, Chatwin H, Evans P . Identification and characterization of a novel family of Drosophila beta-adrenergic-like octopamine G-protein coupled receptors. J Neurochem. 2005; 94(2):547-60. DOI: 10.1111/j.1471-4159.2005.03251.x. View

Rebollar E, Valadez-Graham V, Vazquez M, Reynaud E, Zurita M . Role of the p53 homologue from Drosophila melanogaster in the maintenance of histone H3 acetylation and response to UV-light irradiation. FEBS Lett. 2006; 580(2):642-8. DOI: 10.1016/j.febslet.2005.12.083. View

Rodriguez-Valentin R, Lopez-Gonzalez I, Jorquera R, Labarca P, Zurita M, Reynaud E . Oviduct contraction in Drosophila is modulated by a neural network that is both, octopaminergic and glutamatergic. J Cell Physiol. 2006; 209(1):183-98. DOI: 10.1002/jcp.20722. View

10.

Violin J, DiPilato L, Yildirim N, Elston T, Zhang J, Lefkowitz R . beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. J Biol Chem. 2007; 283(5):2949-61. DOI: 10.1074/jbc.M707009200. View

11.

Lange A . Tyramine: from octopamine precursor to neuroactive chemical in insects. Gen Comp Endocrinol. 2008; 162(1):18-26. DOI: 10.1016/j.ygcen.2008.05.021. View

12.

Verlinden H, Vleugels R, Marchal E, Badisco L, Pfluger H, Blenau W . The role of octopamine in locusts and other arthropods. J Insect Physiol. 2010; 56(8):854-67. DOI: 10.1016/j.jinsphys.2010.05.018. View

13.

Koon A, Ashley J, Barria R, Dasgupta S, Brain R, Waddell S . Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling. Nat Neurosci. 2010; 14(2):190-9. PMC: 3391700. DOI: 10.1038/nn.2716. View

14.

Bissinger B, Donohue K, Khalil S, Grozinger C, Sonenshine D, Zhu J . Synganglion transcriptome and developmental global gene expression in adult females of the American dog tick, Dermacentor variabilis (Acari: Ixodidae). Insect Mol Biol. 2011; 20(4):465-91. DOI: 10.1111/j.1365-2583.2011.01086.x. View

15.

Corley S, Piper E, Jonsson N . Generation of full-length cDNAs for eight putative GPCnR from the cattle tick, R. microplus using a targeted degenerate PCR and sequencing strategy. PLoS One. 2012; 7(3):e32480. PMC: 3293813. DOI: 10.1371/journal.pone.0032480. View

16.

Cossio-Bayugar R, Miranda-Miranda E, Narvaez Padilla V, Olvera-Valencia F, Reynaud E . Perturbation of tyraminergic/octopaminergic function inhibits oviposition in the cattle tick Rhipicephalus (Boophilus) microplus. J Insect Physiol. 2012; 58(5):628-33. DOI: 10.1016/j.jinsphys.2012.01.006. View

17.

Abbas R, Zaman M, Colwell D, Gilleard J, Iqbal Z . Acaricide resistance in cattle ticks and approaches to its management: the state of play. Vet Parasitol. 2014; 203(1-2):6-20. DOI: 10.1016/j.vetpar.2014.03.006. View

18.

Fuchs S, Rende E, Crisanti A, Nolan T . Disruption of aminergic signalling reveals novel compounds with distinct inhibitory effects on mosquito reproduction, locomotor function and survival. Sci Rep. 2014; 4:5526. PMC: 4078307. DOI: 10.1038/srep05526. View

19.

Li Y, Fink C, El-Kholy S, Roeder T . The octopamine receptor octß2R is essential for ovulation and fertilization in the fruit fly Drosophila melanogaster. Arch Insect Biochem Physiol. 2014; 88(3):168-78. DOI: 10.1002/arch.21211. View

20.

Marlin G, Thompson P, Reddel H, Chow C, Cheng S . Bronchodilator activity of prazosin in patients with allergic rhinitis and asthma. Br J Clin Pharmacol. 1982; 13(3):445-8. PMC: 1402106. DOI: 10.1111/j.1365-2125.1982.tb01400.x. View