Defining Obstructive Ventilatory Defect in 2015

Overview

Journal Libyan J Med

Specialty General Medicine

Date 2015 Oct 11

PMID 26452407

Citations 8

Authors

Zied Affes

Salaheddine Rekik

Helmi Ben Saad

Affiliations

Soon will be listed here.

Abstract

Introduction: There is no clear consensus as to what constitutes an obstructive ventilatory defect (OVD): Is it FEV1/FVC<lower limit of normal (LLN) or<0.70 (respectively, physiological and operational definitions)?

Aim: To determine, according to the two definitions, the percentage of subjects having an OVD among them explored in a lung function exploration laboratory.

Population And Methods: This is a retrospective study including 4,730 subjects aged 17-85 years. Subjects were divided according to the presence [physio (+) or operat (+)] or absence [physio (-) or operat (-)] of an OVD, and into younger (<45 years, n=2,076), older (≥45 years, n=2,654), smokers (n=1,208), and non-smokers (n=3,522) groups.

Results: For the total sample, the younger and older groups [mean±SD of age (years), respectively, 46.7±14.1; 33.9±7.4, and 56.8±9.1], the 'physiological definition' detected, respectively, 13.46, 43.22, and 5.09% more OVD than the 'operational one' (p<0.05). In addition, the operational definition, compared with the physiological one, overdiagnosed OVD in 2.33 and 0.44% of smokers and non-smokers, respectively, and underdiagnosed it in 4.46% and 29.72% of smokers and non-smokers, respectively (p<0.05). Compared with the group 'physio (-), operat (+)', the 'physio (+), operat (-)' one was younger (74.2±4.7 years vs. 40.9±10.3 years) and had significantly higher FEV1 (62±13% vs. 78±17%) and FVC (71±15% vs. 93±19%).

Conclusion: The frequency of OVD much depends on the criteria used for its definition.

Citing Articles

Routine pulmonary lung function tests: Interpretative strategies and challenges.

Barkous B, Briki C, Boubakri S, Abdesslem M, Ben Abbes N, Ben Hmid W Chron Respir Dis. 2024; 21:14799731241307252.

PMID: 39644209 PMC: 11625406. DOI: 10.1177/14799731241307252.

Automated evaluation of typical patient-ventilator asynchronies based on lung hysteretic responses.

Chen Y, Zhang K, Zhou C, Chase J, Hu Z Biomed Eng Online. 2023; 22(1):102.

PMID: 37875890 PMC: 10598979. DOI: 10.1186/s12938-023-01165-0.

Spirometric Patterns in Patients with Sleep-Related Breathing Disorders: Some Points to Highlight.

Ben Saad H J Family Med Prim Care. 2022; 11(6):3376-3377.

PMID: 36119345 PMC: 9480820. DOI: 10.4103/jfmpc.jfmpc_411_21.

Review of the current use of global lung function initiative norms for spirometry (GLI-2012) and static lung volumes (GLI-2021) in Great Arab Maghreb (GAM) countries and steps required to improve their utilization.

Ben Saad H Libyan J Med. 2022; 17(1):2031596.

PMID: 35080480 PMC: 8794060. DOI: 10.1080/19932820.2022.2031596.

The multi-ethnic global lung initiative 2012 (GLI-2012) norms reflect contemporary adult's Algerian spirometry.

Ketfi A, Gharnaout M, Bougrida M, Ben Saad H PLoS One. 2018; 13(9):e0203023.

PMID: 30180191 PMC: 6122801. DOI: 10.1371/journal.pone.0203023.

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