Association of ATP-Binding Cassette Transporter A1 Gene Polymorphisms in Type 2 Diabetes Mellitus Among Malaysians

Overview

Journal J Diabetes Res

Publisher Wiley

Specialty Endocrinology

Date 2015 Oct 10

PMID 26451383

Citations 11

Authors

Polin Haghvirdizadeh

Vasudevan Ramachandran

Ali Etemad

Farzad Heidari

Nooshin Ghodsian

Norzian Bin Ismail

Patimah Ismail

Affiliations

Soon will be listed here.

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a complex polygenic disorder characterized by impaired insulin resistance, insulin secretion, and dysregulation of lipid and protein metabolism with environmental and genetic factors. ATP-binding cassette transporter A1 (ABCA1) gene polymorphisms are reported as the one of the genetic risk factors for T2DM in various populations with conflicting results. This study was conducted based on PCR-HRM to determine the frequency of ABCA1 gene by rs2230806 (R219K), rs1800977 (C69T), and rs9282541 (R230C) polymorphisms Malaysian subjects.

Methods: A total of 164 T2DM and 165 controls were recruited and their genotypes for ABCA1 gene polymorphisms were determined based on the real time high resolution melting analysis.

Results: There was a significant difference between the subjects in terms of age, BMI, FPG, HbA1c, HDL, LDL, and TG (P < 0.05). There was a significant association between HOM of R219K (P = 0.005), among Malaysian subjects; moreover, allele frequency revealed the significant difference in A allele of R219K (P = 0.003). But, there was no significant difference in genotypic and allelic frequencies of C69T and R230C polymorphism.

Conclusion: R219K polymorphism of ABCA1 gene can be considered as a genetic risk factor for T2DM subjects among Malaysians.

Citing Articles

C69T Gene Polymorphism Association with Dysglycemia in Saudi Prediabetic Adults.

Ajabnoor G, Bahijri S, Alrashidi W, Enani S, Alamoudi A, Al Sheikh L Genes (Basel). 2022; 13(12).

PMID: 36553543 PMC: 9777653. DOI: 10.3390/genes13122277.

Diabetes and Familial Hypercholesterolemia: Interplay between Lipid and Glucose Metabolism.

Gonzalez-Lleo A, Sanchez-Hernandez R, Boronat M, Wagner A Nutrients. 2022; 14(7).

PMID: 35406116 PMC: 9002616. DOI: 10.3390/nu14071503.

Association between the ABCA1 (R219K) polymorphism and lipid profiles: a meta-analysis.

Shi Z, Tian Y, Zhao Z, Wu Y, Hu X, Li J Sci Rep. 2021; 11(1):21718.

PMID: 34741058 PMC: 8571387. DOI: 10.1038/s41598-021-00961-9.

Association between Gene Polymorphisms and Plasma Lipid Concentration: A Systematic Review and Meta-Analysis.

Shim S, Yoon H, Yee J, Han J, Gwak H J Pers Med. 2021; 11(9).

PMID: 34575660 PMC: 8466567. DOI: 10.3390/jpm11090883.

69C>T Polymorphism and the Risk of Type 2 Diabetes Mellitus: A Systematic Review and Updated Meta-Analysis.

Yoon H, Lee M, Song Y, Yee J, Song G, Gwak H Front Endocrinol (Lausanne). 2021; 12:639524.

PMID: 33967955 PMC: 8104122. DOI: 10.3389/fendo.2021.639524.

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