Emerging Therapeutic Options for Sporadic Inclusion Body Myositis

Overview

Journal Ther Clin Risk Manag

Publisher Dove Medical Press

Date 2015 Oct 8

PMID 26445546

Citations 3

Authors

Lindsay N Alfano

Linda P Lowes

Affiliations

Soon will be listed here.

Abstract

Sporadic inclusion body myositis is the most common inflammatory muscle disorder preferentially affecting males over the age of 40 years. Progressive muscle weakness of the finger flexors and quadriceps muscles results in loss of independence with activities of daily living and eventual wheelchair dependence. Initial signs of disease are often overlooked and can lead to mis- or delayed diagnosis. The underlying cause of disease is unknown, and disease progression appears refractory to available treatment options. This review discusses the clinical presentation of inclusion body myositis and the current efforts in diagnosis, and focuses on the current state of research for both nonpharmacological and pharmacological treatment options for this patient group.

Citing Articles

Whole-body-electro-myostimulation for the care of inclusion body myositis-A case report.

Freitag N, Dragutinovic B, Notbohm H, Filipovic A, Schiffer T, Bloch W Clin Case Rep. 2024; 12(11):e9539.

PMID: 39479585 PMC: 11522995. DOI: 10.1002/ccr3.9539.

A cross-sectional study of hand function in inclusion body myositis: Implications for functional rating scale.

Lin A, Clapp M, Karanja E, Dooley K, Weihl C, Wang L Neuromuscul Disord. 2020; 30(3):200-206.

PMID: 32057637 PMC: 9724478. DOI: 10.1016/j.nmd.2019.12.002.

Multicenter questionnaire survey for sporadic inclusion body myositis in Japan.

Suzuki N, Mori-Yoshimura M, Yamashita S, Nakano S, Murata K, Inamori Y Orphanet J Rare Dis. 2016; 11(1):146.

PMID: 27821140 PMC: 5100251. DOI: 10.1186/s13023-016-0524-x.

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