Tumor Necrosis Factor-alpha G-238A Polymorphism and Coronary Artery Disease Risk: a Meta-analysis of 4,222 Patients and 4,832 Controls

Overview

Journal Ther Clin Risk Manag

Publisher Dove Medical Press

Date 2015 Oct 8

PMID 26445542

Citations 2

Authors

Xian-Ping Hua

Xiao-Dong Zhang

Joey Sw Kwong

Xian-Tao Zeng

Zhen-Jian Zhang

Wan-Lin Wei

Affiliations

Soon will be listed here.

Abstract

Background: The aim of the present study was to investigate the association between tumor necrosis factor-alpha (TNF-α) gene G-238A polymorphism and risk of coronary artery disease (CAD) using a meta-analytical approach.

Methods: The PubMed and Embase databases were searched for relevant publications up to January 13, 2015. Four authors (XPH, XDZ, XTZ, and ZJZ) independently selected the studies, extracted, and analyzed the data using the Comprehensive Meta-Analysis software. The sensitivity and subgroups analyses were also performed. Either a fixed effects or a random effects model was used to estimate pooled odds ratios (ORs) and their 95% confidence intervals (CIs).

Results: Finally, ten articles including eleven case-control studies involving 4,222 patients and 4,832 controls were yielded. The results indicated no significant association between G-238A polymorphism and CAD risk (A vs G: OR =1.08, 95% CI =0.89-1.30; AA vs GG: OR =1.15, 95% CI =0.59-2.25; GA vs GG: OR =1.14, 95% CI =0.88-1.48; AA vs [GG + GA]: OR =1.09, 95% CI =0.56-2.14; (GA + AA) vs GG: OR =1.11, 95% CI =0.90-1.38). In the subgroup analyses, similar results were obtained with overall populations. The sensitivity analyses showed that the overall results were robust. No publication bias was detected.

Conclusion: Based on current evidence, we can conclude that TNF-α G-238A polymorphism might not be associated with CAD risk.

Citing Articles

Proteomics analysis of coronary atherosclerotic heart disease with different Traditional Chinese Medicine syndrome types before and after percutaneous coronary intervention.

Zhibo W, Ying L, Daoping W, Bo M, Lan M, Junguo R J Tradit Chin Med. 2024; 44(3):554-563.

PMID: 38767640 PMC: 11077157. DOI: 10.19852/j.cnki.jtcm.20240408.001.

Plasma Proteome Profiling of Coronary Artery Disease Patients: Downregulation of Transthyretin-An Important Event.

Monu , Kharb R, Sharma A, Chaddar M, Yadav R, Agnihotri P Mediators Inflamm. 2020; 2020:3429541.

PMID: 33299376 PMC: 7707994. DOI: 10.1155/2020/3429541.

References

Konenkov V, Shevchenko A, Prokofev V, Maksimov V . [Complex of genotypes of cytokines as a genetic factor of risk of development of myocardial infarction of in Europien population of Russia men]. Kardiologiia. 2012; 52(7):22-9. View

Ohira T, Iso H . Cardiovascular disease epidemiology in Asia: an overview. Circ J. 2013; 77(7):1646-52. DOI: 10.1253/circj.cj-13-0702. View

Xu Q, Yuan F, Shen X, Wen H, Li W, Cheng B . Polymorphisms of C242T and A640G in CYBA gene and the risk of coronary artery disease: a meta-analysis. PLoS One. 2014; 9(1):e84251. PMC: 3879292. DOI: 10.1371/journal.pone.0084251. View

Falvo J, Tsytsykova A, Goldfeld A . Transcriptional control of the TNF gene. Curr Dir Autoimmun. 2010; 11:27-60. PMC: 4785889. DOI: 10.1159/000289196. View

Cheng K, Zhao Y, Liu L, Wan J . Tumor necrosis factor-α 238 G/A polymorphism and risk of hepatocellular carcinoma: evidence from a meta-analysis. Asian Pac J Cancer Prev. 2013; 14(5):3275-9. DOI: 10.7314/apjcp.2013.14.5.3275. View

Ghazouani L, Ben Hadj Khalifa S, Abboud N, Ben Hamda K, Ben Khalfallah A, Brahim N . TNF-alpha -308G>A and IL-6 -174G>C polymorphisms in Tunisian patients with coronary artery disease. Clin Biochem. 2010; 43(13-14):1085-9. DOI: 10.1016/j.clinbiochem.2010.05.005. View

Allen R . Polymorphism of the human TNF-alpha promoter--random variation or functional diversity?. Mol Immunol. 2000; 36(15-16):1017-27. DOI: 10.1016/s0161-5890(99)00127-3. View

Yan Y, Weng H, Shen Z, Wu L, Zeng X . Association between interleukin-4 gene -590 c/t, -33 c/t, and 70-base-pair polymorphisms and periodontitis susceptibility: a meta-analysis. J Periodontol. 2014; 85(11):e354-62. DOI: 10.1902/jop.2014.140317. View

Zhang L, Chen L, Wang M, Chen X, Li N, Huang Y . The G894t, T-786c and 4b/a polymorphisms in Enos gene and cancer risk: a meta-analysis. J Evid Based Med. 2015; 7(4):263-9. DOI: 10.1111/jebm.12126. View

10.

Pereira T, Rudnicki M, Franco R, Pereira A, Krieger J . Effect of the G-308A polymorphism of the tumor necrosis factor alpha gene on the risk of ischemic heart disease and ischemic stroke: a meta-analysis. Am Heart J. 2007; 153(5):821-30. DOI: 10.1016/j.ahj.2007.02.031. View

11.

Lieb W, Vasan R . Genetics of coronary artery disease. Circulation. 2013; 128(10):1131-8. PMC: 3881185. DOI: 10.1161/CIRCULATIONAHA.113.005350. View

12.

Herrmann S, Ricard S, Nicaud V, Mallet C, Arveiler D, Evans A . Polymorphisms of the tumour necrosis factor-alpha gene, coronary heart disease and obesity. Eur J Clin Invest. 1998; 28(1):59-66. DOI: 10.1046/j.1365-2362.1998.00244.x. View

13.

Song G, Choi S, Ji J, Lee Y . Association between tumor necrosis factor-α promoter -308 A/G, -238 A/G, interleukin-6 -174 G/C and -572 G/C polymorphisms and periodontal disease: a meta-analysis. Mol Biol Rep. 2013; 40(8):5191-203. DOI: 10.1007/s11033-013-2621-4. View

14.

Sukhinina T, Shakhnovich R, Barsova R, Matveeva N, Titov B, Sudomoina M . [Value of allele gene polymorphism of the inflammation system for prognosis of patients with myocardial infarction]. Kardiologiia. 2012; 52(3):15-21. View

15.

Zhang H, Xie S, Wang J, Chen Y, Wang Y, Huang T . Tumor necrosis factor-alpha G-308A gene polymorphism and coronary heart disease susceptibility: an updated meta-analysis. Thromb Res. 2011; 127(5):400-5. DOI: 10.1016/j.thromres.2010.12.018. View

16.

Wang X, Zhang J, Du X, Song M, Jia C, Liu H . Association of A561C and G98T polymorphisms in E-selectin gene with coronary artery disease: a meta-analysis. PLoS One. 2013; 8(11):e79301. PMC: 3832468. DOI: 10.1371/journal.pone.0079301. View

17.

Sudomoina M, Sukhinina T, Barsova R, Favorov A, Shakhnovich R, Titov B . [Complex analsis of association of inflammation genes with myocardial infarction]. Mol Biol (Mosk). 2010; 44(3):463-71. View

18.

Chu H, Yang J, Mi S, Bhuyan S, Li J, Zhong L . Tumor necrosis factor-alpha G-308 A polymorphism and risk of coronary heart disease and myocardial infarction: A case-control study and meta-analysis. J Cardiovasc Dis Res. 2012; 3(2):84-90. PMC: 3354475. DOI: 10.4103/0975-3583.95359. View

19.

Szabo G . The role and importance of gene polymorphisms in the development of atherosclerosis. Interv Med Appl Sci. 2013; 5(1):46-51. PMC: 3831799. DOI: 10.1556/IMAS.5.2013.1.10. View

20.

Muhlestein J . Secondary prevention of coronary artery disease with antimicrobials: current status and future directions. Am J Cardiovasc Drugs. 2004; 2(2):107-18. DOI: 10.2165/00129784-200202020-00004. View