Autologous Oocyte Cryopreservation in Women Aged 40 and Older Using Minimal Stimulation IVF

Overview

Journal Reprod Biol Endocrinol

Publisher Biomed Central

Specialties Endocrinology
Reproductive Medicine

Date 2015 Oct 8

PMID 26444973

Citations 1

Authors

John J Zhang

Simon Choo

Mingxue Yang

Affiliations

Soon will be listed here.

Abstract

Background: The value of oocyte cryopreservation in older women remains controversial. The aim of this study was to report the oocyte freezing experience in women aged 40 and older at a single fertility center.

Findings: One hundred fifty eight women (mean age 43.9 ± 0.2) who underwent minimal ovarian stimulation IVF were enrolled. IVF protocol included the use of clomiphene citrate (50 mg/day) or letrozole (2.5 mg/day) with or without low dose gonadotropins (started at 75 IU/day and increased as needed to 150 IU/day). 584 retrieved oocytes (2.1 ± 0.15 per patient) yielded 532 mature MII oocytes that were frozen. After thawing and fertilization by ICSI, a total of 344 embryos (1.9 ± 0.1 per patient) were formed. A total of 57 relatively good embryos were transferred and yielded three live births (5.3 % per embryo transfer), three spontaneous abortions, and one chemical pregnancy.

Conclusions: These data are important in counseling older women who desire autologous oocyte freezing.

Citing Articles

Social oocyte cryopreservation: a portrayal of Brazilian women.

Santo E, Dieamant F, Petersen C, Mauri A, Vagnini L, Renzi A JBRA Assist Reprod. 2017; 21(2):101-104.

PMID: 28609276 PMC: 5473702. DOI: 10.5935/1518-0557.20170024.

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