Stress-Induced Mutagenesis

Overview

Journal EcoSal Plus

Publisher American Society for Microbiology

Specialty Microbiology

Date 2015 Oct 8

PMID 26442828

Citations 11

Authors

Ashley B Williams

Patricia L Foster

Affiliations

Soon will be listed here.

Abstract

Early research on the origins and mechanisms of mutation led to the establishment of the dogma that, in the absence of external forces, spontaneous mutation rates are constant. However, recent results from a variety of experimental systems suggest that mutation rates can increase in response to selective pressures. This chapter summarizes data demonstrating that,under stressful conditions, Escherichia coli and Salmonella can increase the likelihood of beneficial mutations by modulating their potential for genetic change.Several experimental systems used to study stress-induced mutagenesis are discussed, with special emphasison the Foster-Cairns system for "adaptive mutation" in E. coli and Salmonella. Examples from other model systems are given to illustrate that stress-induced mutagenesis is a natural and general phenomenon that is not confined to enteric bacteria. Finally, some of the controversy in the field of stress-induced mutagenesis is summarized and discussed, and a perspective on the current state of the field is provided.

Citing Articles

Harnessing microbial heterogeneity for improved biosynthesis fueled by synthetic biology.

Cao Y, Li J, Liu L, Du G, Liu Y Synth Syst Biotechnol. 2024; 10(1):281-293.

PMID: 39686977 PMC: 11646789. DOI: 10.1016/j.synbio.2024.11.004.

Genomic alterations involved in fluoroquinolone resistance development in Staphylococcus aureus.

Huynh T, Tran V, Thai V, Nguyen H, Nguyen N, Tran M PLoS One. 2023; 18(7):e0287973.

PMID: 37494330 PMC: 10370734. DOI: 10.1371/journal.pone.0287973.

Mutation Rate and Spectrum of the Silkworm in Normal and Temperature Stress Conditions.

Han M, Ren J, Guo H, Tong X, Hu H, Lu K Genes (Basel). 2023; 14(3).

PMID: 36980921 PMC: 10048334. DOI: 10.3390/genes14030649.

Rapid evolution of mutation rate and spectrum in response to environmental and population-genetic challenges.

Wei W, Ho W, Behringer M, Miller S, Bcharah G, Lynch M Nat Commun. 2022; 13(1):4752.

PMID: 35963846 PMC: 9376063. DOI: 10.1038/s41467-022-32353-6.

Complex Ecotype Dynamics Evolve in Response to Fluctuating Resources.

Behringer M, Ho W, Meraz J, Miller S, Boyer G, Stone C mBio. 2022; 13(3):e0346721.

PMID: 35575545 PMC: 9239185. DOI: 10.1128/mbio.03467-21.

References

Pinson V, Takahashi M, Rouviere-Yaniv J . Differential binding of the Escherichia coli HU, homodimeric forms and heterodimeric form to linear, gapped and cruciform DNA. J Mol Biol. 1999; 287(3):485-97. DOI: 10.1006/jmbi.1999.2631. View

Foster P . Are adaptive mutations due to a decline in mismatch repair? The evidence is lacking. Mutat Res. 1999; 436(2):179-84. PMC: 2921617. DOI: 10.1016/s1383-5742(98)00023-4. View

Autret S, Levine A, Vannier F, Fujita Y, Seror S . The replication checkpoint control in Bacillus subtilis: identification of a novel RTP-binding sequence essential for the replication fork arrest after induction of the stringent response. Mol Microbiol. 1999; 31(6):1665-79. DOI: 10.1046/j.1365-2958.1999.01299.x. View

Wright B, LONGACRE A, Reimers J . Hypermutation in derepressed operons of Escherichia coli K12. Proc Natl Acad Sci U S A. 1999; 96(9):5089-94. PMC: 21821. DOI: 10.1073/pnas.96.9.5089. View

Foster P, Rosche W . Increased episomal replication accounts for the high rate of adaptive mutation in recD mutants of Escherichia coli. Genetics. 1999; 152(1):15-30. PMC: 1460594. DOI: 10.1093/genetics/152.1.15. View

Rosche W, Foster P . The role of transient hypermutators in adaptive mutation in Escherichia coli. Proc Natl Acad Sci U S A. 1999; 96(12):6862-7. PMC: 22007. DOI: 10.1073/pnas.96.12.6862. View

Rudner R, Murray A, Huda N . Is there a link between mutation rates and the stringent response in Bacillus subtilis?. Ann N Y Acad Sci. 1999; 870:418-22. DOI: 10.1111/j.1749-6632.1999.tb08917.x. View

Harris R, Feng G, Ross K, Sidhu R, Thulin C, Longerich S . Mismatch repair is diminished during stationary-phase mutation. Mutat Res. 1999; 437(1):51-60. View

Al Mamun A, Rahman M, Humayun M . Escherichia coli cells bearing mutA, a mutant glyV tRNA gene, express a recA-dependent error-prone DNA replication activity. Mol Microbiol. 1999; 33(4):732-40. DOI: 10.1046/j.1365-2958.1999.01520.x. View

10.

Timms A, Muriel W, Bridges B . A UmuD,C-dependent pathway for spontaneous G:C to C:G transversions in stationary phase Escherichia coli mut Y. Mutat Res. 1999; 435(1):77-80. DOI: 10.1016/s0921-8777(99)00035-x. View

11.

Brake A, Fowler A, Zabin I, Kania J, Muller-Hill B . beta-Galactosidase chimeras: primary structure of a lac repressor-beta-galactosidase protein. Proc Natl Acad Sci U S A. 1978; 75(10):4824-7. PMC: 336213. DOI: 10.1073/pnas.75.10.4824. View

12.

Zechiedrich E, Khodursky A, Bachellier S, Schneider R, Chen D, Lilley D . Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli. J Biol Chem. 2000; 275(11):8103-13. DOI: 10.1074/jbc.275.11.8103. View

13.

BULL H, McKenzie G, Hastings P, ROSENBERG S . Evidence that stationary-phase hypermutation in the Escherichia coli chromosome is promoted by recombination. Genetics. 2000; 154(4):1427-37. PMC: 1461015. DOI: 10.1093/genetics/154.4.1427. View

14.

Kvint K, Farewell A, Nystrom T . RpoS-dependent promoters require guanosine tetraphosphate for induction even in the presence of high levels of sigma(s). J Biol Chem. 2000; 275(20):14795-8. DOI: 10.1074/jbc.C000128200. View

15.

Fernandez de Henestrosa A, Ogi T, Aoyagi S, Chafin D, HAYES J, Ohmori H . Identification of additional genes belonging to the LexA regulon in Escherichia coli. Mol Microbiol. 2000; 35(6):1560-72. DOI: 10.1046/j.1365-2958.2000.01826.x. View

16.

McKenzie G, Harris R, Lee P, ROSENBERG S . The SOS response regulates adaptive mutation. Proc Natl Acad Sci U S A. 2000; 97(12):6646-51. PMC: 18688. DOI: 10.1073/pnas.120161797. View

17.

Kornberg A, Rao N . Inorganic polyphosphate: a molecule of many functions. Annu Rev Biochem. 2000; 68:89-125. DOI: 10.1146/annurev.biochem.68.1.89. View

18.

Wagner J, Nohmi T . Escherichia coli DNA polymerase IV mutator activity: genetic requirements and mutational specificity. J Bacteriol. 2000; 182(16):4587-95. PMC: 94631. DOI: 10.1128/JB.182.16.4587-4595.2000. View

19.

Zhao J, Winkler M . Reduction of GC --> TA transversion mutation by overexpression of MutS in Escherichia coli K-12. J Bacteriol. 2000; 182(17):5025-8. PMC: 111390. DOI: 10.1128/JB.182.17.5025-5028.2000. View

20.

Tsutsumi K, Munekata M, Shiba T . Involvement of inorganic polyphosphate in expression of SOS genes. Biochim Biophys Acta. 2000; 1493(1-2):73-81. DOI: 10.1016/s0167-4781(00)00165-2. View