Stealing the Keys to the Kitchen: Viral Manipulation of the Host Cell Metabolic Network

Overview

Journal Trends Microbiol

Date 2015 Oct 7

PMID 26439298

Citations 101

Authors

Christopher M Goodwin

Shihao Xu

Joshua Munger

Affiliations

Soon will be listed here.

Abstract

Host cells possess the metabolic assets required for viral infection. Recent studies indicate that control of the host's metabolic resources is a core host-pathogen interaction. Viruses have evolved mechanisms to usurp the host's metabolic resources, funneling them towards the production of virion components as well as the organization of specialized compartments for replication, maturation, and dissemination. Consequently, hosts have developed a variety of metabolic countermeasures to sense and resist these viral changes. The complex interplay between virus and host over metabolic control has only just begun to be deconvoluted. However, it is clear that virally induced metabolic reprogramming can substantially impact infectious outcomes, highlighting the promise of targeting these processes for antiviral therapeutic development.

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References

Fontaine K, Sanchez E, Camarda R, Lagunoff M . Dengue virus induces and requires glycolysis for optimal replication. J Virol. 2014; 89(4):2358-66. PMC: 4338897. DOI: 10.1128/JVI.02309-14. View

Tang C, Loeliger E, Luncsford P, Kinde I, Beckett D, Summers M . Entropic switch regulates myristate exposure in the HIV-1 matrix protein. Proc Natl Acad Sci U S A. 2003; 101(2):517-22. PMC: 327179. DOI: 10.1073/pnas.0305665101. View

Tong X, Zhao F, Thompson C . The molecular determinants of de novo nucleotide biosynthesis in cancer cells. Curr Opin Genet Dev. 2009; 19(1):32-7. PMC: 2707261. DOI: 10.1016/j.gde.2009.01.002. View

Purushotham A, Schug T, Xu Q, Surapureddi S, Guo X, Li X . Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 2009; 9(4):327-38. PMC: 2668535. DOI: 10.1016/j.cmet.2009.02.006. View

Clemente M, Alvarez S, Serramia M, Martinez-Bonet M, Munoz-Fernandez M . Prostaglandin E2 reduces the release and infectivity of new cell-free virions and cell-to-cell HIV-1 transfer. PLoS One. 2014; 9(2):e85230. PMC: 3934822. DOI: 10.1371/journal.pone.0085230. View

Maceyka M, Spiegel S . Sphingolipid metabolites in inflammatory disease. Nature. 2014; 510(7503):58-67. PMC: 4320971. DOI: 10.1038/nature13475. View

Yu Y, Maguire T, Alwine J . Human cytomegalovirus infection induces adipocyte-like lipogenesis through activation of sterol regulatory element binding protein 1. J Virol. 2012; 86(6):2942-9. PMC: 3302344. DOI: 10.1128/JVI.06467-11. View

Ritter J, Wahl A, Freund S, Genzel Y, Reichl U . Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling. BMC Syst Biol. 2010; 4:61. PMC: 2890500. DOI: 10.1186/1752-0509-4-61. View

Goujon C, Riviere L, Jarrosson-Wuilleme L, Bernaud J, Rigal D, Darlix J . SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells. Retrovirology. 2007; 4:2. PMC: 1779362. DOI: 10.1186/1742-4690-4-2. View

10.

Saad J, Miller J, Tai J, Kim A, Ghanam R, Summers M . Structural basis for targeting HIV-1 Gag proteins to the plasma membrane for virus assembly. Proc Natl Acad Sci U S A. 2006; 103(30):11364-9. PMC: 1544092. DOI: 10.1073/pnas.0602818103. View

11.

Luo S, Hu K, He S, Wang P, Zhang M, Huang X . Contribution of N-linked glycans on HSV-2 gB to cell-cell fusion and viral entry. Virology. 2015; 483:72-82. DOI: 10.1016/j.virol.2015.04.005. View

12.

Towler M, Grahame Hardie D . AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res. 2007; 100(3):328-41. DOI: 10.1161/01.RES.0000256090.42690.05. View

13.

Fontaine K, Camarda R, Lagunoff M . Vaccinia virus requires glutamine but not glucose for efficient replication. J Virol. 2014; 88(8):4366-74. PMC: 3993723. DOI: 10.1128/JVI.03134-13. View

14.

Demers A, Ran Z, Deng Q, Wang D, Edman B, Lu W . Palmitoylation is required for intracellular trafficking of influenza B virus NB protein and efficient influenza B virus growth in vitro. J Gen Virol. 2014; 95(Pt 6):1211-1220. PMC: 4027035. DOI: 10.1099/vir.0.063511-0. View

15.

Spencer C, Schafer X, Moorman N, Munger J . Human cytomegalovirus induces the activity and expression of acetyl-coenzyme A carboxylase, a fatty acid biosynthetic enzyme whose inhibition attenuates viral replication. J Virol. 2011; 85(12):5814-24. PMC: 3126312. DOI: 10.1128/JVI.02630-10. View

16.

Xu K, Nagy P . Expanding use of multi-origin subcellular membranes by positive-strand RNA viruses during replication. Curr Opin Virol. 2014; 9:119-26. DOI: 10.1016/j.coviro.2014.09.015. View

17.

Vastag L, Koyuncu E, Grady S, Shenk T, Rabinowitz J . Divergent effects of human cytomegalovirus and herpes simplex virus-1 on cellular metabolism. PLoS Pathog. 2011; 7(7):e1002124. PMC: 3136460. DOI: 10.1371/journal.ppat.1002124. View

18.

Soni S, Stahelin R . The Ebola virus matrix protein VP40 selectively induces vesiculation from phosphatidylserine-enriched membranes. J Biol Chem. 2014; 289(48):33590-7. PMC: 4246110. DOI: 10.1074/jbc.M114.586396. View

19.

Heaton N, Perera R, Berger K, Khadka S, LaCount D, Kuhn R . Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. Proc Natl Acad Sci U S A. 2010; 107(40):17345-50. PMC: 2951450. DOI: 10.1073/pnas.1010811107. View

20.

Diamond T, Roshal M, Jamburuthugoda V, Reynolds H, Merriam A, Lee K . Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase. J Biol Chem. 2004; 279(49):51545-53. PMC: 1351161. DOI: 10.1074/jbc.M408573200. View