Calcification Characteristics of Low-Flow Low-Gradient Severe Aortic Stenosis in Patients Undergoing Transcatheter Aortic Valve Replacement

Overview

Journal Cardiol Res Pract

Publisher Wiley

Specialty Cardiology & Vascular Diseases

Date 2015 Oct 6

PMID 26435875

Citations 1

Authors

Barbara E Stahli

Thi Dan Linh Nguyen-Kim

Catherine Gebhard

Thomas Frauenfelder

Felix C Tanner

Fabian Nietlispach

Francesco Maisano

Volkmar Falk

Thomas F Luscher

Willibald Maier

Ronald K Binder

Affiliations

Soon will be listed here.

Abstract

Low-flow low-gradient severe aortic stenosis (LFLGAS) is associated with worse outcomes. Aortic valve calcification patterns of LFLGAS as compared to non-LFLGAS have not yet been thoroughly assessed. 137 patients undergoing transcatheter aortic valve replacement (TAVR) with preprocedural multidetector computed tomography (MDCT) and postprocedural transthoracic echocardiography were enrolled. Calcification characteristics were assessed by MDCT both for the total aortic valve and separately for each leaflet. 34 patients had LFLGAS and 103 non-LFLGAS. Total aortic valve calcification volume (p < 0.001), mass (p < 0.001), and density (p = 0.004) were lower in LFLGAS as compared to non-LFLGAS patients. At 30-day follow-up, mean transaortic pressure gradients and more than mild paravalvular regurgitation did not differ between groups. In conclusion, LFLGAS and non-LFLGAS express different calcification patterns which, however, did not impact on device success after TAVR.

Citing Articles

Transcatheter Aortic Valve Replacement Across Hemodynamic Subtypes of Severe Aortic Valve Stenosis: A Network Meta-analysis.

Ullah W, Sana M, Mukhtar M, Syed S, Zahid S, Alkhouli M J Soc Cardiovasc Angiogr Interv. 2024; 3(3Part A):101255.

PMID: 39131772 PMC: 11307878. DOI: 10.1016/j.jscai.2023.101255.

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