Guiding Dengue Vaccine Development Using Knowledge Gained from the Success of the Yellow Fever Vaccine

Overview

Journal Cell Mol Immunol

Date 2015 Oct 6

PMID 26435066

Citations 16

Authors

Huabin Liang

Min Lee

Xia Jin

Affiliations

Soon will be listed here.

Abstract

Flaviviruses comprise approximately 70 closely related RNA viruses. These include several mosquito-borne pathogens, such as yellow fever virus (YFV), dengue virus (DENV), and Japanese encephalitis virus (JEV), which can cause significant human diseases and thus are of great medical importance. Vaccines against both YFV and JEV have been used successfully in humans for decades; however, the development of a DENV vaccine has encountered considerable obstacles. Here, we review the protective immune responses elicited by the vaccine against YFV to provide some insights into the development of a protective DENV vaccine.

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