Deregulation of F-box Proteins and Its Consequence on Cancer Development, Progression and Metastasis

Overview

Journal Semin Cancer Biol

Specialty Oncology

Date 2015 Oct 4

PMID 26432751

Citations 29

Authors

Jinho Heo

Rebeka Eki

Tarek Abbas

Affiliations

Soon will be listed here.

Abstract

F-box proteins are substrate receptors of the SCF (SKP1-Cullin 1-F-box protein) E3 ubiquitin ligase that play important roles in a number of physiological processes and activities. Through their ability to assemble distinct E3 ubiquitin ligases and target key regulators of cellular activities for ubiquitylation and degradation, this versatile group of proteins is able to regulate the abundance of cellular proteins whose deregulated expression or activity contributes to disease. In this review, we describe the important roles of select F-box proteins in regulating cellular activities, the perturbation of which contributes to the initiation and progression of a number of human malignancies.

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