Role of Oxidative Stress in Modulating Unfolded Protein Response Activity in Chronic Myeloid Leukemia Cell Line

Overview

Journal Iran Biomed J

Specialties Biology
General Medicine

Date 2015 Oct 4

PMID 26432458

Citations 6

Authors

Ali Bazi

Mohammad Reza Keramati

Mehran Gholamin

Affiliations

Soon will be listed here.

Abstract

Unlabelled: Recently, it has been revealed that tyrosine kinase inhibitors (TKIs) act through inducing both oxidative and endoplasmic reticulum (ER) stress in chronic myeloid leukemia cells. However, ER stress signaling triggers both apoptotic and survival processes within cells. Nevertheless, mechanisms by which TKIs avoid the pro-survival effects are not clear. The aim of this study was to evaluate the potential role of oxidative stress in activity of unfolded protein response (UPR) survival pathway within K562 cell line.

Methods: The expression of UPR survival target genes, Xbp1, and Grp94 (glucose requiring protein 94) was studied in single and combined exposure to oxidative and ER stress in K562 cell line by quantitative and qualitative PCR.

Results: The expression of UPR-related survival gene Grp94 was hampered by exposing to oxidative stress in cell induced with ER stress.

Conclusion: Interaction of oxidative and ER stress may role as a mediator influencing UPR signaling activity.

Citing Articles

Oxidative Stress and Chronic Myeloid Leukemia: A Balance between ROS-Mediated Pro- and Anti-Apoptotic Effects of Tyrosine Kinase Inhibitors.

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Targeting UPR signaling pathway by dasatinib as a promising therapeutic approach in chronic myeloid leukemia.

Ozel B, Kipcak S, Biray Avci C, Takanlou M, Takanlou L, Tezcanli Kaymaz B Med Oncol. 2022; 39(9):126.

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The contrast agent 2,3,5-triiodobenzoic acid (TIBA) induces cell death in tumor cells through the generation of reactive oxygen species.

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PMID: 34196897 DOI: 10.1007/s11033-021-06524-5.

Involvement of Oxidative Stress in Resistance to Tyrosine-Kinase Inhibitors Therapy in Chronic Myeloid Leukemia.

Pascu VInturiS E, Gaman A Curr Health Sci J. 2021; 46(4):420-432.

PMID: 33717518 PMC: 7948018. DOI: 10.12865/CHSJ.46.04.14.

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Wang F, Zuo Z, Chen K, Fang J, Cui H, Geng Y Oxid Med Cell Longev. 2020; 2020:6829271.

PMID: 32685099 PMC: 7338970. DOI: 10.1155/2020/6829271.

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