Identification and Characterization of Macrophage Inflammatory Protein 2

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1989 Jan 1

PMID 2643119

Citations 170

Authors

S D Wolpe

B Sherry

D Juers

G Davatelis

R W Yurt

A Cerami

Affiliations

Soon will be listed here.

Abstract

In response to endotoxin, macrophages secrete a protein with a molecular mass of approximately 6000 Da and with an affinity for heparin. This protein, which we term "macrophage inflammatory protein 2," is a potent chemotactic agent for human polymorphonuclear leukocytes. In addition, subcutaneous administration of the monokine causes a localized inflammatory reaction. Partial N-terminal sequence data reveal similarity to a family of proteins, the archetype of which is platelet factor 4. Although macrophage inflammatory protein 2 is a distinct member of the platelet factor 4 family, its sequence is most closely related to that of the gro/KC gene product, which is expressed in transformed or platelet-derived growth factor-treated cells.

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