Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes

Overview

Journal Sci Rep

Specialty Science

Date 2015 Oct 1

PMID 26419607

Citations 7

Authors

Lihua Lu

Hai-Jing Zhong

Modi Wang

See-Lok Ho

Hung-Wing Li

Chung-Hang Leung

Dik-Lung Ma

Affiliations

Soon will be listed here.

Abstract

We report herein the application of kinetically inert luminescent iridium(III) complexes as dual inhibitors and probes of beta-amyloid fibrillogenesis. These iridium(III) complexes inhibited Aβ1-40 peptide aggregation in vitro, and protected against Aβ-induced cytotoxicity in neuronal cells. Furthermore, the complexes differentiated between the aggregated and unaggregated forms of Aβ1-40 peptide on the basis of their emission response.

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References

Ma D, Chan D, Ma V, Leung K, Zhong H, Leung C . Current advancements in Aβ luminescent probes and inhibitors of Aβ aggregation. Curr Alzheimer Res. 2012; 9(7):830-43. DOI: 10.2174/156720512802455377. View

Li M, Howson S, Dong K, Gao N, Ren J, Scott P . Chiral metallohelical complexes enantioselectively target amyloid β for treating Alzheimer's disease. J Am Chem Soc. 2014; 136(33):11655-63. DOI: 10.1021/ja502789e. View

Zhao Q, Li F, Huang C . Phosphorescent chemosensors based on heavy-metal complexes. Chem Soc Rev. 2010; 39(8):3007-30. DOI: 10.1039/b915340c. View

Hong H, Rana S, Barrigan L, Shi A, Zhang Y, Zhou F . Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo. J Neurochem. 2009; 108(4):1097-1108. PMC: 2748761. DOI: 10.1111/j.1471-4159.2008.05866.x. View

Reinke A, Ung P, Quintero J, Carlson H, Gestwicki J . Chemical probes that selectively recognize the earliest Aβ oligomers in complex mixtures. J Am Chem Soc. 2010; 132(50):17655-7. PMC: 3005376. DOI: 10.1021/ja106291e. View

Mishra R, Bulic B, Sellin D, Jha S, Waldmann H, Winter R . Small-molecule inhibitors of islet amyloid polypeptide fibril formation. Angew Chem Int Ed Engl. 2008; 47(25):4679-82. DOI: 10.1002/anie.200705372. View

Hong Y, Meng L, Chen S, Leung C, Da L, Faisal M . Monitoring and inhibition of insulin fibrillation by a small organic fluorogen with aggregation-induced emission characteristics. J Am Chem Soc. 2011; 134(3):1680-9. DOI: 10.1021/ja208720a. View

Beck P, Dubiella C, Groll M . Covalent and non-covalent reversible proteasome inhibition. Biol Chem. 2012; 393(10):1101-20. DOI: 10.1515/hsz-2012-0212. View

Patonay G, Salon J, Sowell J, Strekowski L . Noncovalent labeling of biomolecules with red and near- infrared dyes. Molecules. 2007; 9(3):40-9. PMC: 6147306. DOI: 10.3390/90300040. View

10.

Arai T, Araya T, Sasaki D, Taniguchi A, Sato T, Sohma Y . Rational design and identification of a non-peptidic aggregation inhibitor of amyloid-β based on a pharmacophore motif obtained from cyclo[-Lys-Leu-Val-Phe-Phe-]. Angew Chem Int Ed Engl. 2014; 53(31):8236-9. DOI: 10.1002/anie.201405109. View

11.

Hardy J, Selkoe D . The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science. 2002; 297(5580):353-6. DOI: 10.1126/science.1072994. View

12.

Yamin G, Ruchala P, Teplow D . A peptide hairpin inhibitor of amyloid beta-protein oligomerization and fibrillogenesis. Biochemistry. 2009; 48(48):11329-31. DOI: 10.1021/bi901325g. View

13.

Sathish V, Babu E, Ramdass A, Lu Z, Velayudham M, Thanasekaran P . Alkoxy bridged binuclear rhenium (I) complexes as a potential sensor for β-amyloid aggregation. Talanta. 2014; 130:274-9. DOI: 10.1016/j.talanta.2014.06.070. View

14.

Cheng B, Gong H, Xiao H, Petersen R, Zheng L, Huang K . Inhibiting toxic aggregation of amyloidogenic proteins: a therapeutic strategy for protein misfolding diseases. Biochim Biophys Acta. 2013; 1830(10):4860-71. DOI: 10.1016/j.bbagen.2013.06.029. View

15.

Collin F, Sasaki I, Eury H, Faller P, Hureau C . Pt(II) compounds interplay with Cu(II) and Zn(II) coordination to the amyloid-β peptide has metal specific consequences on deleterious processes associated to Alzheimer's disease. Chem Commun (Camb). 2013; 49(21):2130-2. DOI: 10.1039/c3cc38537j. View

16.

Barnham K, Kenche V, Ciccotosto G, Smith D, Tew D, Liu X . Platinum-based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease. Proc Natl Acad Sci U S A. 2008; 105(19):6813-8. PMC: 2383936. DOI: 10.1073/pnas.0800712105. View

17.

Streltsov V, Epa V, James S, Churches Q, Caine J, Kenche V . Structural insights into the interaction of platinum-based inhibitors with the Alzheimer's disease amyloid-β peptide. Chem Commun (Camb). 2013; 49(97):11364-6. DOI: 10.1039/c3cc47326k. View

18.

Lorenzo A, Yankner B . Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci U S A. 1994; 91(25):12243-7. PMC: 45413. DOI: 10.1073/pnas.91.25.12243. View

19.

Ma G, Huang F, Pu X, Jia L, Jiang T, Li L . Identification of [PtCl2(phen)] binding modes in amyloid-β peptide and the mechanism of aggregation inhibition. Chemistry. 2011; 17(41):11657-66. DOI: 10.1002/chem.201101859. View

20.

Cohen T, Frydman-Marom A, Rechter M, Gazit E . Inhibition of amyloid fibril formation and cytotoxicity by hydroxyindole derivatives. Biochemistry. 2006; 45(15):4727-35. DOI: 10.1021/bi051525c. View