MicroRNAs; Easy and Potent Targets in Optimizing Therapeutic Methods in Reparative Angiogenesis

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2015 Sep 30

PMID 26416208

Citations 6

Authors

Fatemeh Pourrajab

Abbas Vakili Zarch

Seyedhossein Hekmatimoghaddam

Mohamad Reza Zare-Khormizi

Affiliations

Soon will be listed here.

Abstract

The age-related senescence of adult tissues is associated with the decreased level of angiogenic capability and with the development of a degenerative disease such as atherosclerosis which thereafter result in the deteriorating function of multiple systems. Findings indicate that tissue senescence not only diminishes repair processes but also promotes atherogenesis, serving as a double-edged sword in the development and prognosis of ischaemia-associated diseases. Evidence evokes microRNAs (miRNAs) as molecular switchers that underlie cellular events in different tissues. Here, miRNAs would promote new potential targets for optimizing therapeutic methods in blood flow recovery to the ischaemic area. Effectively beginning an ischaemia therapy, a more characteristic of miRNA changes in adult tissues is prerequisite and in the forefront. It may also be a preliminary phase in treatment strategies by stem cell-based therapy.

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