» Articles » PMID: 26414153

Cellular Signaling Pathways Implicated in Metastasis of Colorectal Cancer and the Associated Targeted Agents

Overview
Journal Future Oncol
Specialty Oncology
Date 2015 Sep 29
PMID 26414153
Citations 19
Authors
Affiliations
Soon will be listed here.
Abstract

Colorectal cancer (CRC) is the third leading cancer worldwide and CRC-related death is mainly attributed to metastasis. Many cellular signaling pathways have been demonstrated to be aberrant in colorectal tumors, and some of them lead to the acquisition of malignant phenotypes. Therefore, the evaluation of signaling pathways implicated in CRC metastasis is urgent for further understanding of CRC progression and pharmacotherapy. This review focuses on several novel cellular signaling pathways associated with CRC metastasis, including Wnt/β-catenin, p53, COX, TGF-β/Smad, NF-κB, Notch, VEGF and JAKs/STAT3 signaling pathways. Targeted agents developed based on these pathways are also briefly discussed.

Citing Articles

Interaction of the intestinal cytokines-JAKs-STAT3 and 5 axes with RNA N6-methyladenosine to promote chronic inflammation-induced colorectal cancer.

Esmaeili N, Bakheet A, Tse W, Liu S, Han X Front Oncol. 2024; 14:1352845.

PMID: 39136000 PMC: 11317299. DOI: 10.3389/fonc.2024.1352845.


Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression.

Sanchez-Ramirez D, Mendoza-Rodriguez M, Aleman O, Candanedo-Gonzalez F, Rodriguez-Sosa M, Montesinos-Montesinos J World J Gastrointest Oncol. 2024; 16(5):1705-1724.

PMID: 38764833 PMC: 11099434. DOI: 10.4251/wjgo.v16.i5.1705.


Pathways and molecules for overcoming immunotolerance in metastatic gastrointestinal tumors.

Gan Q, Li Y, Li Y, Liu H, Chen D, Liu L Front Immunol. 2024; 15:1359914.

PMID: 38646539 PMC: 11026648. DOI: 10.3389/fimmu.2024.1359914.


Function and mechanism of MCM8 in the development and progression of colorectal cancer.

Yu S, Dai W, Zhao S, Yang Y, Xu Y, Wang J J Transl Med. 2023; 21(1):623.

PMID: 37710286 PMC: 10503009. DOI: 10.1186/s12967-023-04084-9.


Interplay between Signaling Pathways and Tumor Microenvironment Components: A Paradoxical Role in Colorectal Cancer.

Ben Hamouda S, Essafi-Benkhadir K Int J Mol Sci. 2023; 24(6).

PMID: 36982677 PMC: 10057671. DOI: 10.3390/ijms24065600.