» Articles » PMID: 26412967

Peripheral Biomarker Candidates of Posttraumatic Stress Disorder

Overview
Journal Exp Neurobiol
Specialty Neurology
Date 2015 Sep 29
PMID 26412967
Citations 7
Authors
Affiliations
Soon will be listed here.
Abstract

There is high variability in the manifestation of physical and mental health problems following exposure to trauma and disaster. Although most people may show a range of acute symptoms in the aftermath of traumatic events, chronic and persistent mental disorders may not be developed in all individuals who were exposed to traumatic events. The most common long-term pathological consequence after trauma exposure is posttraumatic stress disorder (PTSD). However, comorbid conditions including depression, anxiety disorder, substance use-related problems, and a variety of other symptoms may frequently be observed in individuals with trauma exposure. Post-traumatic syndrome (PTS) is defined collectively as vast psychosocial problems that could be experienced in response to traumatic events. It is important to predict who will continue to suffer from physical and mental health problems and who will recover following trauma exposure. However, given the heterogeneity and variability in symptom manifestations, it is difficult to find identify biomarkers which predict the development of PTSD. In this review, we will summarize the results of recent studies with regard to putative biomarkers of PTSD and suggest future research directions for biomarker discovery for PTSD.

Citing Articles

Abnormal intestinal milieu in posttraumatic stress disorder is not impacted by treatment that improves symptoms.

Voigt R, Zalta A, Raeisi S, Zhang L, Brown J, Forsyth C Am J Physiol Gastrointest Liver Physiol. 2022; 323(2):G61-G70.

PMID: 35638693 PMC: 9291416. DOI: 10.1152/ajpgi.00066.2022.


Current and future functional imaging techniques for post-traumatic stress disorder.

Prasad A, Chaichi A, Kelley D, Francis J, Gartia M RSC Adv. 2022; 9(42):24568-24594.

PMID: 35527877 PMC: 9069787. DOI: 10.1039/c9ra03562a.


Neuroendocrine drivers of risk and resilience: The influence of metabolism & mitochondria.

Turkson S, Kloster A, Hamilton P, Neigh G Front Neuroendocrinol. 2019; 54:100770.

PMID: 31288042 PMC: 6886586. DOI: 10.1016/j.yfrne.2019.100770.


PTSD Biomarker Database: deep dive metadatabase for PTSD biomarkers, visualizations and analysis tools.

Domingo-Fernandez D, Provost A, Tom Kodamullil A, Marin-Llao J, Lasseter H, Diaz K Database (Oxford). 2019; 2019.

PMID: 31260040 PMC: 6601392. DOI: 10.1093/database/baz081.


Polygenic risk associated with post-traumatic stress disorder onset and severity.

Misganaw B, Guffanti G, Lori A, Abu-Amara D, Flory J, Mueller S Transl Psychiatry. 2019; 9(1):165.

PMID: 31175274 PMC: 6555815. DOI: 10.1038/s41398-019-0497-3.


References
1.
Sah R, Ekhator N, Strawn J, Sallee F, Baker D, Horn P . Low cerebrospinal fluid neuropeptide Y concentrations in posttraumatic stress disorder. Biol Psychiatry. 2009; 66(7):705-7. PMC: 4751867. DOI: 10.1016/j.biopsych.2009.04.037. View

2.
Matsuoka Y, Nishi D, Noguchi H, Kim Y, Hashimoto K . Longitudinal changes in serum brain-derived neurotrophic factor in accident survivors with posttraumatic stress disorder. Neuropsychobiology. 2013; 68(1):44-50. DOI: 10.1159/000350950. View

3.
Zhang L, Li H, Hu X, Benedek D, Fullerton C, Forsten R . Mitochondria-focused gene expression profile reveals common pathways and CPT1B dysregulation in both rodent stress model and human subjects with PTSD. Transl Psychiatry. 2015; 5:e580. PMC: 4490278. DOI: 10.1038/tp.2015.65. View

4.
. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework. Clin Pharmacol Ther. 2001; 69(3):89-95. DOI: 10.1067/mcp.2001.113989. View

5.
Miller M, Sadeh N . Traumatic stress, oxidative stress and post-traumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis. Mol Psychiatry. 2014; 19(11):1156-62. PMC: 4211971. DOI: 10.1038/mp.2014.111. View