A Blueprint to Address Research Gaps in the Development of Biomarkers for Pediatric Tuberculosis

Overview

Journal Clin Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2015 Sep 27

PMID 26409279

Citations 15

Authors

Mark Patrick Nicol

Devasena Gnanashanmugam

Renee Browning

Eleanor S Click

Luis E Cuevas

Anne Detjen

Steve M Graham

Michael Levin

Mamodikoe Makhene

Payam Nahid

Carlos M Perez-Velez

Klaus Reither

Rinn Song

Hans M L Spiegel

Carol Worrell

Heather J Zar

Gerhard Walzl

Affiliations

Soon will be listed here.

Abstract

Childhood tuberculosis contributes significantly to the global tuberculosis disease burden but remains challenging to diagnose due to inadequate methods of pathogen detection in paucibacillary pediatric samples and lack of a child-specific host biomarker to identify disease. Accurately diagnosing tuberculosis in children is required to improve case detection, surveillance, healthcare delivery, and effective advocacy. In May 2014, the National Institutes of Health convened a workshop including researchers in the field to delineate priorities to address this research gap. This blueprint describes the consensus from the workshop, identifies critical research steps to advance this field, and aims to catalyze efforts toward harmonization and collaboration in this area.

Citing Articles

Feasibility and utility of a combined nasogastric-tube-and-string-test device for bacteriologic confirmation of pulmonary tuberculosis in young children.

Khambati N, Song R, Smith J, Bijker E, McCarthy K, Click E Diagn Microbiol Infect Dis. 2024; 109(3):116302.

PMID: 38657352 PMC: 11128341. DOI: 10.1016/j.diagmicrobio.2024.116302.

QuantiFERON Gold-In-Tube for the diagnosis of mycobacterial tuberculosis infection in children under 5 years of age: A systematic review and meta-analysis.

Volkman T, Muruganandah V, Graham H, Tosif S, Stokes S, Ranganathan S PLoS One. 2024; 19(1):e0295913.

PMID: 38166111 PMC: 10760833. DOI: 10.1371/journal.pone.0295913.

Host-Based Biomarkers in Saliva for the Diagnosis of Pulmonary Tuberculosis in Children: A Mini-Review.

Khambati N, Olbrich L, Ellner J, Salgame P, Song R, Bijker E Front Pediatr. 2021; 9:756043.

PMID: 34760853 PMC: 8575443. DOI: 10.3389/fped.2021.756043.

Integration of metabolomics and transcriptomics reveals novel biomarkers in the blood for tuberculosis diagnosis in children.

Dutta N, Tornheim J, Fukutani K, Paradkar M, Tiburcio R, Kinikar A Sci Rep. 2020; 10(1):19527.

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A three-marker protein biosignature distinguishes tuberculosis from other respiratory diseases in Gambian children.

Togun T, Hoggart C, Agbla S, Gomez M, Egere U, Sillah A EBioMedicine. 2020; 58:102909.

PMID: 32711253 PMC: 7381493. DOI: 10.1016/j.ebiom.2020.102909.

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