Clinical Trial Methodology and Drug-placebo Differences

Overview

Journal World Psychiatry

Specialty Psychiatry

Date 2015 Sep 27

PMID 26407779

Citations 3

Authors

Irving Kirsch

Affiliations

Soon will be listed here.

Citing Articles

Placebo response mitigation with a participant-focused psychoeducational procedure: a randomized, single-blind, all placebo study in major depressive and psychotic disorders.

Cohen E, Hassman H, Ereshefsky L, Walling D, Grindell V, Keefe R Neuropsychopharmacology. 2020; 46(4):844-850.

PMID: 33244149 PMC: 8026614. DOI: 10.1038/s41386-020-00911-5.

Raising Placebo Efficacy in Antidepressant Trials Across Decades Explained by Small-Study Effects: A Meta-Reanalysis.

Holper L Front Psychiatry. 2020; 11:633.

PMID: 32848900 PMC: 7399231. DOI: 10.3389/fpsyt.2020.00633.

Personalized prediction of antidepressant v. placebo response: evidence from the EMBARC study.

Webb C, Trivedi M, Cohen Z, Dillon D, Fournier J, Goer F Psychol Med. 2018; 49(7):1118-1127.

PMID: 29962359 PMC: 6314923. DOI: 10.1017/S0033291718001708.

References

Kirsch I . The placebo effect revisited: lessons learned to date. Complement Ther Med. 2013; 21(2):102-4. DOI: 10.1016/j.ctim.2012.12.003. View

Sinyor M, Levitt A, Cheung A, Schaffer A, Kiss A, Dowlati Y . Does inclusion of a placebo arm influence response to active antidepressant treatment in randomized controlled trials? Results from pooled and meta-analyses. J Clin Psychiatry. 2010; 71(3):270-9. DOI: 10.4088/JCP.08r04516blu. View

Khan A, Brown W . Antidepressants versus placebo in major depression: an overview. World Psychiatry. 2015; 14(3):294-300. PMC: 4592645. DOI: 10.1002/wps.20241. View

Rutherford B, Sneed J, Roose S . Does study design influence outcome?. The effects of placebo control and treatment duration in antidepressant trials. Psychother Psychosom. 2009; 78(3):172-81. PMC: 3785090. DOI: 10.1159/000209348. View

Walsh B, Seidman S, Sysko R, Gould M . Placebo response in studies of major depression: variable, substantial, and growing. JAMA. 2002; 287(14):1840-7. DOI: 10.1001/jama.287.14.1840. View