Stress and the Brain: Individual Variability and the Inverted-U

Overview

Journal Nat Neurosci

Date 2015 Sep 26

PMID 26404708

Citations 142

Authors

Robert M Sapolsky

Affiliations

Soon will be listed here.

Citing Articles

Conceptualizing Personality as Individualized Allostasis: Exploring a Balanced Measure of Personality for Psychotherapy/Psychophysiology Integration.

Steffen P, Olsen J Appl Psychophysiol Biofeedback. 2025; .

PMID: 40072793 DOI: 10.1007/s10484-025-09700-6.

Applying evidence-based cross-disciplinary concepts helps to explain the heterogeneity in pain, function, and biological measures in individuals with knee pain with/at risk of osteoarthritis.

Mickle A, Tanner J, Holmes 3rd U, Rashid A, Barolette O, Addison B Pain Rep. 2024; 10(1):e1225.

PMID: 39726853 PMC: 11671054. DOI: 10.1097/PR9.0000000000001225.

Adverse childhood experiences, subsequent negative life events, and their impact on health in occupational rehabilitation patients: a mixed-methods study.

Eftedal M, Johansen T, Del Risco Kollerud R Front Rehabil Sci. 2024; 5:1389337.

PMID: 39606585 PMC: 11599175. DOI: 10.3389/fresc.2024.1389337.

Stress Molecular Signaling in Interaction With Cognition.

Lugenbuhl J, Viho E, Binder E, Daskalakis N Biol Psychiatry. 2024; 97(4):349-358.

PMID: 39368530 PMC: 11896655. DOI: 10.1016/j.biopsych.2024.09.023.

Examining the applicability of virtual battle space for stress management training in military personnel-A validation study.

Schilder F, Withagen F, de Weijer A, Bruinsma B, Geuze E Stress Health. 2024; 40(6):e3475.

PMID: 39340715 PMC: 11636437. DOI: 10.1002/smi.3475.

References

McEwen B, Bowles N, Gray J, Hill M, Hunter R, Karatsoreos I . Mechanisms of stress in the brain. Nat Neurosci. 2015; 18(10):1353-63. PMC: 4933289. DOI: 10.1038/nn.4086. View

Caspi A, Sugden K, Moffitt T, Taylor A, Craig I, Harrington H . Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science. 2003; 301(5631):386-9. DOI: 10.1126/science.1083968. View

Tost H, Champagne F, Meyer-Lindenberg A . Environmental influence in the brain, human welfare and mental health. Nat Neurosci. 2015; 18(10):1421-31. DOI: 10.1038/nn.4108. View

Baldi E, Bucherelli C . The inverted "u-shaped" dose-effect relationships in learning and memory: modulation of arousal and consolidation. Nonlinearity Biol Toxicol Med. 2009; 3(1):9-21. PMC: 2657842. DOI: 10.2201/nonlin.003.01.002. View

Hodes G, Kana V, Menard C, Merad M, Russo S . Neuroimmune mechanisms of depression. Nat Neurosci. 2015; 18(10):1386-93. PMC: 4843114. DOI: 10.1038/nn.4113. View

Calhoon G, Tye K . Resolving the neural circuits of anxiety. Nat Neurosci. 2015; 18(10):1394-404. PMC: 7575249. DOI: 10.1038/nn.4101. View

Hariri A, Holmes A . Finding translation in stress research. Nat Neurosci. 2015; 18(10):1347-52. PMC: 4693288. DOI: 10.1038/nn.4111. View

Prager E, Johnson L . Stress at the synapse: signal transduction mechanisms of adrenal steroids at neuronal membranes. Sci Signal. 2009; 2(86):re5. DOI: 10.1126/scisignal.286re5. View

Chrousos G . Stress and disorders of the stress system. Nat Rev Endocrinol. 2009; 5(7):374-81. DOI: 10.1038/nrendo.2009.106. View

10.

Luksys G, Sandi C . Neural mechanisms and computations underlying stress effects on learning and memory. Curr Opin Neurobiol. 2011; 21(3):502-8. DOI: 10.1016/j.conb.2011.03.003. View

11.

Chattarji S, Tomar A, Suvrathan A, Ghosh S, Rahman M . Neighborhood matters: divergent patterns of stress-induced plasticity across the brain. Nat Neurosci. 2015; 18(10):1364-75. DOI: 10.1038/nn.4115. View

12.

Fiorillo C, Tobler P, Schultz W . Discrete coding of reward probability and uncertainty by dopamine neurons. Science. 2003; 299(5614):1898-902. DOI: 10.1126/science.1077349. View

13.

Arnsten A . Stress weakens prefrontal networks: molecular insults to higher cognition. Nat Neurosci. 2015; 18(10):1376-85. PMC: 4816215. DOI: 10.1038/nn.4087. View

14.

Sapolsky R, Romero L, Munck A . How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev. 2000; 21(1):55-89. DOI: 10.1210/edrv.21.1.0389. View

15.

McEwen B, Sapolsky R . Stress and cognitive function. Curr Opin Neurobiol. 1995; 5(2):205-16. DOI: 10.1016/0959-4388(95)80028-x. View

16.

Russo S, Murrough J, Han M, Charney D, Nestler E . Neurobiology of resilience. Nat Neurosci. 2012; 15(11):1475-84. PMC: 3580862. DOI: 10.1038/nn.3234. View

17.

Roozendaal B . 1999 Curt P. Richter award. Glucocorticoids and the regulation of memory consolidation. Psychoneuroendocrinology. 2000; 25(3):213-38. DOI: 10.1016/s0306-4530(99)00058-x. View

18.

Sorrells S, Caso J, Munhoz C, Sapolsky R . The stressed CNS: when glucocorticoids aggravate inflammation. Neuron. 2009; 64(1):33-9. PMC: 4782919. DOI: 10.1016/j.neuron.2009.09.032. View

19.

Diamond D, Bennett M, Fleshner M, Rose G . Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation. Hippocampus. 1992; 2(4):421-30. DOI: 10.1002/hipo.450020409. View

20.

Hollon N, Burgeno L, Phillips P . Stress effects on the neural substrates of motivated behavior. Nat Neurosci. 2015; 18(10):1405-12. PMC: 4721524. DOI: 10.1038/nn.4114. View