Near-IR Light-Mediated Cleavage of Antibody-Drug Conjugates Using Cyanine Photocages

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2015 Sep 26

PMID 26403799

Citations 66

Authors

Roger R Nani

Alexander P Gorka

Tadanobu Nagaya

Hisataka Kobayashi

Martin J Schnermann

Affiliations

Soon will be listed here.

Abstract

Despite significant progress in the clinical application of antibody drug conjugates (ADCs), novel cleavage strategies that provide improved selectivity are still needed. Herein is reported the first approach that uses near-IR light to cleave a small molecule from a biomacromolecule, and its application to the problem of ADC linkage. The preparation of cyanine antibody conjugates, drug cleavage mediated by 690 nm light, and initial in vitro and in vivo evaluation is described. These studies provide the critical chemical underpinning from which to develop this near-IR light cleavable linker strategy.

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