Innate Immune Cells in the Pathogenesis of Primary Systemic Vasculitis

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 2015 Sep 26

PMID 26403285

Citations 6

Authors

Durga Prasanna Misra

Vikas Agarwal

Affiliations

Soon will be listed here.

Abstract

Innate immune system forms the first line of defense against foreign substances. Neutrophils, eosinophils, erythrocytes, platelets, monocytes, macrophages, dendritic cells, γδ T cells, natural killer and natural killer T cells comprise the innate immune system. Genetic polymorphisms influencing the activation of innate immune cells predispose to development of vasculitis and influence its severity. Abnormally activated innate immune cells cross-talk with other cells of the innate immune system, present antigens more efficiently and activate T and B lymphocytes and cause tissue destruction via cell-mediated cytotoxicity and release of pro-inflammatory cytokines. These secreted cytokines further recruit other cells to the sites of vascular injury. They are involved in both the initiation as well as the perpetuation of vasculitis. Evidences suggest reversal of aberrant activation of immune cells in response to therapy. Understanding the role of innate immune cells in vasculitis helps understand the potential of therapeutic modulation of their activation to treat vasculitis.

Citing Articles

Central Multifocal Choroiditis: Platelet Granularity as a Potential Marker for Treatment With Steroid-Sparing Immunomodulatory Therapy.

de Groot E, Ossewaarde-van Norel J, Hoefer I, Haitjema S, de Boer J, Kuiper J Front Ophthalmol (Lausanne). 2024; 1:784848.

PMID: 38983969 PMC: 11182307. DOI: 10.3389/fopht.2021.784848.

Editorial: Innate immunity in vasculitis.

de Souza A, Ooi J, Misra D, Zhong Y, Brown K Front Immunol. 2024; 15:1432069.

PMID: 38887287 PMC: 11181152. DOI: 10.3389/fimmu.2024.1432069.

The roles of immune cells in Behçet's disease.

Hu D, Guan J Adv Rheumatol. 2023; 63(1):49.

PMID: 37814339 DOI: 10.1186/s42358-023-00328-w.

Mechanisms of thrombosis in ANCA-associated vasculitis.

Misra D, Thomas K, Gasparyan A, Zimba O Clin Rheumatol. 2021; 40(12):4807-4815.

PMID: 34109491 PMC: 8189705. DOI: 10.1007/s10067-021-05790-9.

Extracellular vesicles in autoimmune vasculitis - Little dirts light the fire in blood vessels.

Wu X, Liu Y, Wei W, Liu M Autoimmun Rev. 2019; 18(6):593-606.

PMID: 30959208 PMC: 6956404. DOI: 10.1016/j.autrev.2018.12.007.

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