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Atypical Femoral Fracture Due to Chronic Use of Bisphosphonates: Case Report

Overview
Journal Rev Bras Ortop
Specialty Orthopedics
Date 2015 Sep 25
PMID 26401508
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Abstract

The causal relationship between chronic use of bisphosphonates and occurrences of atypical femoral fractures has not yet been established. Nonetheless, it is known that their chronic use is more related to fractures with a pattern differing from that of classical osteoporotic fractures. Atypical fractures are still rare events and the benefit from using bisphosphonates remains greater for prevention and treatment of osteoporosis. There are few studies guiding the diagnosis and management of these fractures, thus making it difficult to achieve better results. In this report, we present the case of an elderly patient with an atypical femoral fracture that was managed in accordance with guidance from the American Society for Bone and Mineral Research.

References
1.
Ha Y, Cho M, Park K, Kim S, Koo K . Is surgery necessary for femoral insufficiency fractures after long-term bisphosphonate therapy?. Clin Orthop Relat Res. 2010; 468(12):3393-8. PMC: 2974881. DOI: 10.1007/s11999-010-1583-2. View

2.
Aspenberg P, Schilcher J . Atypical femoral fractures, bisphosphonates, and mechanical stress. Curr Osteoporos Rep. 2014; 12(2):189-93. DOI: 10.1007/s11914-014-0200-9. View

3.
Polascik T . Bisphosphonates in oncology: evidence for the prevention of skeletal events in patients with bone metastases. Drug Des Devel Ther. 2009; 3:27-40. PMC: 2769231. View

4.
Schilcher J . Epidemiology, radiology and histology of atypical femoral fractures. Acta Orthop Suppl. 2013; 84(352):1-26. DOI: 10.3109/17453674.2013.850008. View

5.
Ng A, Png M, Chua D, Koh J, Howe T . Review: epidemiology and pathophysiology of atypical femur fractures. Curr Osteoporos Rep. 2014; 12(1):65-73. DOI: 10.1007/s11914-014-0198-z. View