A Fluorescent Probe for H2S in Vivo with Fast Response and High Sensitivity

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2015 Sep 25

PMID 26400755

Citations 10

Authors

H D Li

Q C Yao

J L Fan

N Jiang

J Y Wang

J Xia

X J Peng

Affiliations

Soon will be listed here.

Abstract

In this work, we design and synthesize a new near-infrared (NIR) ratiometric fluorescent probe FD-H2S for the highly sensitive (DL 68.2 nM) detection of H2S with fast response (15 s), large emission shift (220 nm) and excellent enhancement (168-fold in ratiometric value). The probe could be applied for monitoring and imaging of exogenous or endogenous H2S in live MCF-7 cells and in live mice with the fastest response.

Citing Articles

Illuminating Polysulfide Distribution in Lithium Sulfur Batteries; Tracking Polysulfide Shuttle Using Optical Fluorescence Microscopy.

Coke K, Johnson M, Robinson J, Rettie A, Miller T, Shearing P ACS Appl Mater Interfaces. 2024; .

PMID: 38598420 PMC: 11056927. DOI: 10.1021/acsami.3c14612.

Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species.

Fosnacht K, Pluth M Chem Rev. 2024; 124(7):4124-4257.

PMID: 38512066 PMC: 11141071. DOI: 10.1021/acs.chemrev.3c00683.

Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies.

Lin H, Yu Y, Zhu L, Lai N, Zhang L, Guo Y Redox Biol. 2023; 59:102601.

PMID: 36630819 PMC: 9841368. DOI: 10.1016/j.redox.2023.102601.

HPLC Study of Product Formed in the Reaction of NBD-Derived Fluorescent Probe with Hydrogen Sulfide, Cysteine, -acetylcysteine, and Glutathione.

Slowinski D, Swierczynska M, Romanski J, Podsiadly R Molecules. 2022; 27(23).

PMID: 36500398 PMC: 9736530. DOI: 10.3390/molecules27238305.

A turn-on fluorescent probe with a dansyl fluorophore for hydrogen sulfide sensing.

Yan Y, Chen L, Liu R, Zheng Y, Wang S RSC Adv. 2022; 9(47):27652-27658.

PMID: 35529213 PMC: 9070855. DOI: 10.1039/c9ra04790e.