Relationship of Promising Methods in the Detection of Anthracycline-induced Cardiotoxicity in Breast Cancer Patients

Overview

Journal Cancer Chemother Pharmacol

Specialty Oncology

Date 2015 Sep 25

PMID 26400150

Citations 14

Authors

Ben F Bulten

Hein J Verberne

Louise Bellersen

Wim J G Oyen

Aida Sabate-Llobera

Annelies M C Mavinkurve-Groothuis

Livia Kapusta

Hanneke W M van Laarhoven

Lioe-Fee de Geus-Oei

Affiliations

Soon will be listed here.

Abstract

Purpose: It remains challenging to identify patients at risk of anthracycline-induced cardiotoxicity. To better understand the different risk-stratifying approaches, we evaluated (123)I-metaiodobenzylguanidine ((123)I-mIBG) scintigraphy and its interrelationship with conventional echocardiography, 2D strain imaging and several biomarkers.

Methods: We performed (123)I-mIBG scintigraphy, conventional and strain echocardiography and biomarker (NT-proBNP, TNF-α, galectin-3, IL-6, troponin I, ST-2 and sFlt-1) assessment in 59 breast cancer survivors 1 year after anthracycline treatment. Interobserver and intermethod variability was calculated on planar and SPECT (123)I-mIBG scintigraphy, using the heart/mediastinum (H/M) ratio and washout (WO). Pearson's r and multivariate analyses were performed to identify correlations and independent predictors of (123)I-mIBG scintigraphy results.

Results: Delayed planar anterior whole-heart ROI (WH) H/M ratios and WO were the most robust (123)I-mIBG parameters. Significant correlations were observed between (123)I-mIBG parameters and several conventional echo parameters, global longitudinal and radial strain (GLS and GRS) and galectin-3. The highest Pearson's r was observed between delayed H/M ratio and GRS (Pearson's r 0.36, p = 0.01). Multivariate analysis showed that GRS was the only independent predictor of the delayed WH H/M ratio (p = 0.023).

Conclusion: The delayed planar H/M ratio is the most robust (123)I-mIBG parameter. It correlates with several conventional echocardiographic parameters, GLS, GRS and galectin-3. Of these, only GRS predicts the H/M ratio.

Citing Articles

Biomarkers and Strain Echocardiography for the Detection of Subclinical Cardiotoxicity in Breast Cancer Patients Receiving Anthracyclines.

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The Role of Advanced Cardiovascular Imaging Modalities in Cardio-Oncology: From Early Detection to Unravelling Mechanisms of Cardiotoxicity.

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New Insights in the Era of Clinical Biomarkers as Potential Predictors of Systemic Therapy-Induced Cardiotoxicity in Women with Breast Cancer: A Systematic Review.

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Plasma biomarkers reflecting high oxidative stress in the prediction of myocardial injury due to anthracycline chemotherapy and the effect of carvedilol: insights from the CECCY Trial.

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[I]MIBG is a better early marker of anthracycline cardiotoxicity than [F]FDG: a preclinical SPECT/CT and simultaneous PET/MR study.

Oudot A, Courteau A, Guillemin M, Vrigneaud J, Walker P, Brunotte F EJNMMI Res. 2021; 11(1):92.

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References

Boogers M, Borleffs C, Henneman M, van Bommel R, van Ramshorst J, Boersma E . Cardiac sympathetic denervation assessed with 123-iodine metaiodobenzylguanidine imaging predicts ventricular arrhythmias in implantable cardioverter-defibrillator patients. J Am Coll Cardiol. 2010; 55(24):2769-77. DOI: 10.1016/j.jacc.2009.12.066. View

Shah R, Chen-Tournoux A, Picard M, Van Kimmenade R, Januzzi J . Galectin-3, cardiac structure and function, and long-term mortality in patients with acutely decompensated heart failure. Eur J Heart Fail. 2010; 12(8):826-32. PMC: 2913048. DOI: 10.1093/eurjhf/hfq091. View

Flotats A, Carrio I, Agostini D, Le Guludec D, Marcassa C, Schafers M . Proposal for standardization of 123I-metaiodobenzylguanidine (MIBG) cardiac sympathetic imaging by the EANM Cardiovascular Committee and the European Council of Nuclear Cardiology. Eur J Nucl Med Mol Imaging. 2010; 37(9):1802-12. DOI: 10.1007/s00259-010-1491-4. View

Appel J, Sogaard P, Mortensen C, Skagen K, Nielsen D . Tissue-Doppler assessment of cardiac left ventricular function during short-term adjuvant epirubicin therapy for breast cancer. J Am Soc Echocardiogr. 2011; 24(2):200-6. DOI: 10.1016/j.echo.2010.12.004. View

Chen W, Cao Q, Dilsizian V . Variation of heart-to-mediastinal ratio in (123)I-mIBG cardiac sympathetic imaging: its affecting factors and potential corrections. Curr Cardiol Rep. 2011; 13(2):132-7. DOI: 10.1007/s11886-010-0157-y. View

Ky B, French B, Ruparel K, Sweitzer N, Fang J, Levy W . The vascular marker soluble fms-like tyrosine kinase 1 is associated with disease severity and adverse outcomes in chronic heart failure. J Am Coll Cardiol. 2011; 58(4):386-94. PMC: 3193932. DOI: 10.1016/j.jacc.2011.03.032. View

Chirumamilla A, Travin M . Cardiac applications of 123I-mIBG imaging. Semin Nucl Med. 2011; 41(5):374-87. DOI: 10.1053/j.semnuclmed.2011.04.001. View

Stoodley P, Richards D, Hui R, Boyd A, Harnett P, Meikle S . Two-dimensional myocardial strain imaging detects changes in left ventricular systolic function immediately after anthracycline chemotherapy. Eur J Echocardiogr. 2011; 12(12):945-52. DOI: 10.1093/ejechocard/jer187. View

Aggarwal A, Esler M, Socratous F, Kaye D . Evidence for functional presynaptic alpha-2 adrenoceptors and their down-regulation in human heart failure. J Am Coll Cardiol. 2001; 37(5):1246-51. DOI: 10.1016/s0735-1097(01)01121-4. View

10.

Carrio I . Cardiac neurotransmission imaging. J Nucl Med. 2001; 42(7):1062-76. View

11.

Somsen G, Verberne H, Fleury E, Righetti A . Normal values and within-subject variability of cardiac I-123 MIBG scintigraphy in healthy individuals: implications for clinical studies. J Nucl Cardiol. 2004; 11(2):126-33. DOI: 10.1016/j.nuclcard.2003.10.010. View

12.

Bryg R, Williams G, Labovitz A . Effect of aging on left ventricular diastolic filling in normal subjects. Am J Cardiol. 1987; 59(9):971-4. DOI: 10.1016/0002-9149(87)91136-2. View

13.

Giantris A, Abdurrahman L, Hinkle A, Asselin B, Lipshultz S . Anthracycline-induced cardiotoxicity in children and young adults. Crit Rev Oncol Hematol. 1998; 27(1):53-68. DOI: 10.1016/s1040-8428(97)10007-5. View

14.

Gutierrez-Chico J, Zamorano J, de Isla L, Orejas M, Almeria C, Rodrigo J . Comparison of left ventricular volumes and ejection fractions measured by three-dimensional echocardiography versus by two-dimensional echocardiography and cardiac magnetic resonance in patients with various cardiomyopathies. Am J Cardiol. 2005; 95(6):809-13. DOI: 10.1016/j.amjcard.2004.11.046. View

15.

Lipshultz S, Lipsitz S, Sallan S, Dalton V, Mone S, Gelber R . Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia. J Clin Oncol. 2005; 23(12):2629-36. DOI: 10.1200/JCO.2005.12.121. View

16.

Marwick T . Measurement of strain and strain rate by echocardiography: ready for prime time?. J Am Coll Cardiol. 2006; 47(7):1313-27. DOI: 10.1016/j.jacc.2005.11.063. View

17.

Takemura G, Fujiwara H . Doxorubicin-induced cardiomyopathy from the cardiotoxic mechanisms to management. Prog Cardiovasc Dis. 2007; 49(5):330-52. DOI: 10.1016/j.pcad.2006.10.002. View

18.

Lyu Y, Kerrigan J, Lin C, Azarova A, Tsai Y, Ban Y . Topoisomerase IIbeta mediated DNA double-strand breaks: implications in doxorubicin cardiotoxicity and prevention by dexrazoxane. Cancer Res. 2007; 67(18):8839-46. DOI: 10.1158/0008-5472.CAN-07-1649. View

19.

Agostini D, Verberne H, Burchert W, Knuuti J, Povinec P, Sambuceti G . I-123-mIBG myocardial imaging for assessment of risk for a major cardiac event in heart failure patients: insights from a retrospective European multicenter study. Eur J Nucl Med Mol Imaging. 2007; 35(3):535-46. DOI: 10.1007/s00259-007-0639-3. View

20.

Radulescu D, Pripon S, Radulescu L, Duncea C . Left ventricular diastolic performance in breast cancer survivors treated with anthracyclines. Acta Cardiol. 2008; 63(1):27-32. DOI: 10.2143/AC.63.1.2025328. View