Serum and Aqueous Concentrations of Inflammatory Markers in Diabetic Macular Edema

Overview

Journal Ocul Immunol Inflamm

Publisher Informa Healthcare

Specialty Ophthalmology

Date 2015 Sep 25

PMID 26400051

Citations 18

Authors

M Selim Kocabora

Mehmet Erdem Telli

Korhan Fazil

Sevil Karaman Erdur

Mustafa Ozsutcu

Osman Cekic

Kemal Turgay Ozbilen

Affiliations

Soon will be listed here.

Abstract

Purpose: To investigate the relationship between the serum and aqueous levels of inflammatory markers and diabetic macular edema (DME).

Methods: The study included four patient groups: the healthy control group (n = 23 eyes); the diabetic control group (n = 22 eyes); the groups with and without DME (n = 20 eyes and n = 22 eyes, respectively). The patients were evaluated based on their serum levels of HbA1c, C-reactive protein (CRP) and serum and aqueous levels of tumor necrosis factor-alpha (TNF-α).

Results: Statistically significant differences were present for the serum CRP levels and for the aqueous TNF-α levels between the healthy control group and the group with DME (p = 0.004 and p = 0.03, respectively); for the serum TNF-α levels between the healthy control group and the groups without and with DME (p = 0.009 and p = 0.001, respectively).

Conclusions: Increased serum levels of CRP and serum and aqueous levels of TNF-α in DME suggest that inflammation is involved in the pathogenesis of DME.

Citing Articles

Molecular-Genetic Biomarkers of Diabetic Macular Edema.

Andres-Blasco I, Gallego-Martinez A, Casaroli-Marano R, Di Lauro S, Arevalo J, Pinazo-Duran M J Clin Med. 2024; 13(23).

PMID: 39685883 PMC: 11642322. DOI: 10.3390/jcm13237426.

Molecular and Cellular Mechanisms Involved in the Pathophysiology of Retinal Vascular Disease-Interplay Between Inflammation and Oxidative Stress.

Srejovic J, Muric M, Jakovljevic V, Srejovic I, Sreckovic S, Petrovic N Int J Mol Sci. 2024; 25(21).

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Alisol A, the Eye-Entering Ingredient of , Relieves Macular Edema Through TNF-α as Revealed by UPLC-Triple-TOF/MS, Network Pharmacology, and Zebrafish Verification.

Shen R, Cheng K, Li G, Pan Z, Qiaolongbatu X, Wang Y Drug Des Devel Ther. 2024; 18:3361-3382.

PMID: 39100223 PMC: 11297588. DOI: 10.2147/DDDT.S468119.

Elevated aqueous TNF-α levels are associated with more severe functional and anatomic findings in eyes with diabetic macular oedema.

Chew S, Tran T, Sanfilippo P, Lim L, Sandhu S, Wickremasinghe S Clin Exp Ophthalmol. 2024; 52(9):981-990.

PMID: 39072984 PMC: 11620847. DOI: 10.1111/ceo.14425.

Evaluating peripheral blood inflammatory and metabolic biomarkers as predictors in diabetic retinopathy and diabetic macular edema.

Bhutia C, Kaur P, Singh K, Kaur S Indian J Ophthalmol. 2023; 71(6):2521-2525.

PMID: 37322673 PMC: 10417976. DOI: 10.4103/IJO.IJO_345_23.