Cognate Interaction with INKT Cells Expands IL-10-producing B Regulatory Cells

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2015 Sep 23

PMID 26392556

Citations 22

Authors

Emilie E Vomhof-DeKrey

Jennifer Yates

Thomas Hagglof

Paula Lanthier

Eyal Amiel

Natacha Veerapen

Gurdyal S Besra

Mikael C I Karlsson

Elizabeth A Leadbetter

Affiliations

Soon will be listed here.

Abstract

Successful induction of B-cell activation and memory depends on help from CD4+ T cells. Invariant natural killer T (iNKT) cells (glycolipid-specific, CD1d-restricted innate lymphocytes) provide both cognate (direct) and noncognate (indirect) helper signals to enhance B-cell responses. Both forms of iNKT-cell help induce primary humoral immune responses, but only noncognate iNKT-cell help drives humoral memory and plasma cells. Here, we show that iNKT cognate help for B cells is fundamentally different from the help provided by conventional CD4+ T cells. Cognate iNKT-cell help drives an early, unsustained germinal center B-cell expansion, less reduction of T follicular regulatory cells, an expansion of marginal zone B cells, and early increases in regulatory IL-10-producing B-cell numbers compared with noncognate activation. These results are consistent with a mechanism whereby iNKT cells preferentially provide an innate form of help that does not generate humoral memory and has important implications for the application of glycolipid molecules as vaccine adjuvants.

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