[Grape Seed Proanthocyanidin Extracts Inhibit Lipopolysaccharide of Porphyromonas Gingivalis]

Overview

Journal Shanghai Kou Qiang Yi Xue

Specialty Dentistry

Date 2015 Sep 19

PMID 26383567

Citations 5

Authors

Xiang-ke Ci

Li-pei Chen

Xiao-Yan Ou

Affiliations

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Abstract

Purpose: To study the inhibitory effect of grape seed proanthocyanidin extracts on 1ipopolysacharides of Porphyromonas gingivalis.

Methods: Grape seed proanthocyanidin extracts were double-diluted to different concentrations by two-fold dilution. The effect on Porphyromonas gingivalis was measured by minimal inhibitory concentration (MIC). The inhibition effect of grape seed proanthocyanidin extracts on lipopolysaccharide was measured by limulus assay with 6 concentrations below the minimal inhibitory concentration. SPSS 17.0 software package was used for statistical analysis.

Results: The value of MIC of grape seed proanthocyanidin extracts was 0.8 mg/mL to the strains of the experimental bacteria. The inhibitory effect on lipopolysaccharide enhanced with the increasing of the concentration of grape seed proanthocyanidin extracts within the scope of 0.05 to 0.4 mg/mL (P<0.05,0.01).

Conclusions: Grape seed proanthocyanidin extracts have inhibitory effect on lipopolysaccharide of Porphyromonas gingivalis.

Citing Articles

Effects of grape seed proanthocyanidins on the expression of inflammatory mediators in gingival epithelial cells.

Zhang X, Wu W, Chen X, Fang Z, Ye J, Ou X Hua Xi Kou Qiang Yi Xue Za Zhi. 2024; 40(1):39-44.

PMID: 38596991 PMC: 8905272. DOI: 10.7518/hxkq.2022.01.006.

A Review on Berry Seeds-A Special Emphasis on Their Chemical Content and Health-Promoting Properties.

Slawinska N, Prochon K, Olas B Nutrients. 2023; 15(6).

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Gao Y, Zhang X, Yin J, Du Q, Tu Y, Shi J Molecules. 2019; 24(2).

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[Prevention of infectious diseases through microecology modulation techniques].

Wang H, Kang D, Zhou X, Li Y Hua Xi Kou Qiang Yi Xue Za Zhi. 2018; 36(5):564-567.

PMID: 30465353 PMC: 7041137. DOI: 10.7518/hxkq.2018.05.018.

Porphyromonas gingivalis: An Overview of Periodontopathic Pathogen below the Gum Line.

How K, Song K, Chan K Front Microbiol. 2016; 7:53.

PMID: 26903954 PMC: 4746253. DOI: 10.3389/fmicb.2016.00053.