MiR-203 Acts As a Tumor Suppressor Gene in Osteosarcoma by Regulating RAB22A

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2015 Sep 19

PMID 26382657

Citations 26

Authors

Dawei Yang

Guangpeng Liu

Kunzheng Wang

Affiliations

Soon will be listed here.

Abstract

microRNAs (miRNAs), small noncoding RNAs of 19-25 nt, play an important roles in the pathological processes of tumorigenesis. The object of this study was to study the expression and function of miR-203 and to found its target gene in osteosarcoma. In our study, we found the expression level of miR-203 was significantly downregulated in osteosarcoma cell lines and tissues. In addition, overexpression of miR-203 inhibited the osteosarcoma cell proliferation and migration and inhibited Mesenchymal-to-Epithelial reversion Transition (MErT). Moreover, we identified RAB22A as a direct target of miR-203 and RAB22A overexpression blocks the roles of miR-203 in osteosarcoma cell. Furthermore, we demonstrated that RAB22A expression was upregulated in human osteosarcoma cell lines and tissues. Take together, our results demonstrated that miR-203 act as a tumor suppressor miRNA through regulating RAB22A expression and suggested its involvement in osteosarcoma progression and carcinogenesis.

Citing Articles

Retraction: SRCIN1 Suppressed Osteosarcoma Cell Proliferation and Invasion.

PLoS One. 2023; 18(3):e0282984.

PMID: 36989268 PMC: 10058154. DOI: 10.1371/journal.pone.0282984.

Retraction: miR-203 Acts as a Tumor Suppressor Gene in Osteosarcoma by Regulating RAB22A.

PLoS One. 2023; 18(3):e0282979.

PMID: 36989255 PMC: 10057779. DOI: 10.1371/journal.pone.0282979.

Regulation of the Epithelial to Mesenchymal Transition in Osteosarcoma.

Hinton K, Kirk A, Paul P, Persad S Biomolecules. 2023; 13(2).

PMID: 36830767 PMC: 9953423. DOI: 10.3390/biom13020398.

LncRNA HCG18 Promotes Osteosarcoma Cells Proliferation, Migration, and Invasion in by Regulating miR-34a/RUNX2 Pathway.

Chen Y, Zhang D, Cao Q, He C Biochem Genet. 2022; 61(3):1035-1049.

PMID: 36401685 DOI: 10.1007/s10528-022-10294-5.

Nanoliposomal Delivery of MicroRNA-203 Suppresses Migration of Triple-Negative Breast Cancer through Distinct Target Suppression.

Song S, Johnson K, Lujan H, Pradhan S, Sayes C, Taube J Noncoding RNA. 2021; 7(3).

PMID: 34449670 PMC: 8395754. DOI: 10.3390/ncrna7030045.

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