Endocrine Disruptors in Domestic Animal Reproduction: A Clinical Issue?

Overview

Journal Reprod Domest Anim

Specialties Biology
Reproductive Medicine
Veterinary Medicine

Date 2015 Sep 19

PMID 26382024

Citations 3

Authors

Ulf Magnusson

Sara Persson

Affiliations

Soon will be listed here.

Abstract

The objective of this review was to discuss whether endocrine disruption is a clinical concern in domestic animal reproduction. To that end, we firstly summarize the phenomenon of endocrine disruption, giving examples of the agents of concern and their effects on the mammalian reproductive system. Then there is a brief overview of the literature on endocrine disruptors and domestic animal reproduction. Finally, the clinical implications of endocrine disruptors on the reproductive system of farm animals as well as in dogs and cats are discussed. It is concluded that the evidence for clinical cases of endocrine disruption by chemical pollutants is weak, whereas for phytooestrogens, it is well established. However, there is concern that particular dogs and cats may be exposed to man-made endocrine disruptors.

Citing Articles

The use of induced pluripotent stem cells in domestic animals: a narrative review.

Scarfone R, Pena S, Russell K, Betts D, Koch T BMC Vet Res. 2020; 16(1):477.

PMID: 33292200 PMC: 7722595. DOI: 10.1186/s12917-020-02696-7.

Evaluating the Remote Control of Programmed Cell Death, with or without a Compensatory Cell Proliferation.

Dou X, Chen L, Lei M, Zellmer L, Jia Q, Ling P Int J Biol Sci. 2018; 14(13):1800-1812.

PMID: 30443184 PMC: 6231223. DOI: 10.7150/ijbs.26962.

The impact of bisphenol S on bovine granulosa and theca cells.

Campen K, Lavallee M, Combelles C Reprod Domest Anim. 2018; 53(2):450-457.

PMID: 29330967 PMC: 5847463. DOI: 10.1111/rda.13130.

References

Brevini T, Cillo F, Antonini S, Gandolfi F . Effects of endocrine disrupters on the oocytes and embryos of farm animals. Reprod Domest Anim. 2005; 40(4):291-9. DOI: 10.1111/j.1439-0531.2005.00592.x. View

Fowler P, Bellingham M, Sinclair K, Evans N, Pocar P, Fischer B . Impact of endocrine-disrupting compounds (EDCs) on female reproductive health. Mol Cell Endocrinol. 2011; 355(2):231-9. DOI: 10.1016/j.mce.2011.10.021. View

Beck V, Rohr U, Jungbauer A . Phytoestrogens derived from red clover: an alternative to estrogen replacement therapy?. J Steroid Biochem Mol Biol. 2005; 94(5):499-518. DOI: 10.1016/j.jsbmb.2004.12.038. View

McLachlan J, Tilghman S, Burow M, Bratton M . Environmental signaling and reproduction: a comparative biological and chemical perspective. Mol Cell Endocrinol. 2011; 354(1-2):60-2. PMC: 3641892. DOI: 10.1016/j.mce.2011.11.028. View

Rhind S, Evans N, Bellingham M, Sharpe R, Cotinot C, Mandon-Pepin B . Effects of environmental pollutants on the reproduction and welfare of ruminants. Animal. 2010; 4(7):1227-1239. PMC: 2888112. DOI: 10.1017/S1751731110000595. View

Yeung B, Wan H, Law A, Wong C . Endocrine disrupting chemicals: Multiple effects on testicular signaling and spermatogenesis. Spermatogenesis. 2012; 1(3):231-239. PMC: 3271665. DOI: 10.4161/spmg.1.3.18019. View

Magnusson U, Ljungvall K . Environmental pollutants and dysregulation of male puberty--a comparison among species. Reprod Toxicol. 2013; 44:23-32. DOI: 10.1016/j.reprotox.2013.08.002. View

Jefferson W, Patisaul H, Williams C . Reproductive consequences of developmental phytoestrogen exposure. Reproduction. 2012; 143(3):247-60. PMC: 3443604. DOI: 10.1530/REP-11-0369. View

Petro E, Covaci A, Leroy J, Dirtu A, de Coen W, Bols P . Occurrence of endocrine disrupting compounds in tissues and body fluids of Belgian dairy cows and its implications for the use of the cow as a model to study endocrine disruption. Sci Total Environ. 2010; 408(22):5423-8. DOI: 10.1016/j.scitotenv.2010.07.051. View

10.

Corbel T, Perdu E, Gayrard V, Puel S, Lacroix M, Viguie C . Conjugation and deconjugation reactions within the fetoplacental compartment in a sheep model: a key factor determining bisphenol A fetal exposure. Drug Metab Dispos. 2015; 43(4):467-76. DOI: 10.1124/dmd.114.061291. View

11.

Cerundolo R, Court M, Hao Q, Michel K . Identification and concentration of soy phytoestrogens in commercial dog foods. Am J Vet Res. 2004; 65(5):592-6. DOI: 10.2460/ajvr.2004.65.592. View

12.

Wooten K, Smith P . Canine toys and training devices as sources of exposure to phthalates and bisphenol A: quantitation of chemicals in leachate and in vitro screening for endocrine activity. Chemosphere. 2013; 93(10):2245-53. DOI: 10.1016/j.chemosphere.2013.07.075. View

13.

Leung M, Diaz-Llano G, Smith T . Mycotoxins in pet food: a review on worldwide prevalence and preventative strategies. J Agric Food Chem. 2006; 54(26):9623-35. DOI: 10.1021/jf062363+. View

14.

Sharpe R . Environmental/lifestyle effects on spermatogenesis. Philos Trans R Soc Lond B Biol Sci. 2010; 365(1546):1697-712. PMC: 2871918. DOI: 10.1098/rstb.2009.0206. View

15.

Evans N, Bellingham M, Sharpe R, Cotinot C, Rhind S, Kyle C . Reproduction Symposium: does grazing on biosolids-treated pasture pose a pathophysiological risk associated with increased exposure to endocrine disrupting compounds?. J Anim Sci. 2014; 92(8):3185-98. DOI: 10.2527/jas.2014-7763. View

16.

Desiato R, Bertolini S, Baioni E, Crescio M, Scortichini G, Ubaldi A . Data on milk dioxin contamination linked with the location of fodder croplands allow to hypothesize the origin of the pollution source in an Italian valley. Sci Total Environ. 2014; 499:248-56. DOI: 10.1016/j.scitotenv.2014.08.044. View

17.

Oskam I, Lyche J, Krogenaes A, Thomassen R, Skaare J, Wiger R . Effects of long-term maternal exposure to low doses of PCB126 and PCB153 on the reproductive system and related hormones of young male goats. Reproduction. 2005; 130(5):731-42. DOI: 10.1530/rep.1.00690. View

18.

Bursian S, Kern J, Remington R, Link J, Fitzgerald S . Dietary exposure of mink (Mustela vison) to fish from the upper Hudson River, New York, USA: effects on reproduction and offspring growth and mortality. Environ Toxicol Chem. 2013; 32(4):780-93. DOI: 10.1002/etc.2110. View

19.

Bartelt-Hunt S, Snow D, Kranz W, Mader T, Shapiro C, van Donk S . Effect of growth promotants on the occurrence of endogenous and synthetic steroid hormones on feedlot soils and in runoff from beef cattle feeding operations. Environ Sci Technol. 2012; 46(3):1352-60. DOI: 10.1021/es202680q. View

20.

Ali N, Malik R, Mehdi T, Eqani S, Javeed A, Neels H . Organohalogenated contaminants (OHCs) in the serum and hair of pet cats and dogs: biosentinels of indoor pollution. Sci Total Environ. 2013; 449:29-36. DOI: 10.1016/j.scitotenv.2013.01.037. View