Hypothetical Atopic Dermatitis-Myeloproliferative Neoplasm Syndrome

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2015 Sep 18

PMID 26379670

Citations 1

Authors

Toshiaki Kawakami

Tomoaki Ando

Yuko Kawakami

Affiliations

Soon will be listed here.

Abstract

Atopic dermatitis (AD) is a chronic inflammatory skin disease. Myeloproliferative neoplasms (MPNs) are hematopoietic malignancies caused by uncontrolled proliferation of hematopoietic stem/progenitor cells. Recent studies have described several mutant mice exhibiting both AD-like skin inflammation and MPN. Common pathways for skin inflammation encompass overexpression of thymic stromal lymphopoietin and reduced signaling of epidermal growth factor receptor in the epidermis, while overproduction of granulocyte-colony-stimulating factor by keratinocytes and constitutive activation of Stat5 in hematopoietic stem cells are important for the development of MPN. The murine studies suggest the existence of a similar human disease tentatively termed as the atopic dermatitis-myeloproliferative neoplasm syndrome.

Citing Articles

Primary atopic disorders.

Lyons J, Milner J J Exp Med. 2018; 215(4):1009-1022.

PMID: 29549114 PMC: 5881472. DOI: 10.1084/jem.20172306.

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