The Impacts of a GO-game (Chinese Chess) Intervention on Alzheimer Disease in a Northeast Chinese Population

Overview

Journal Front Aging Neurosci

Specialty Geriatrics

Date 2015 Sep 18

PMID 26379544

Citations 14

Authors

Qiao Lin

Yunpeng Cao

Jie Gao

Affiliations

Soon will be listed here.

Abstract

A GO game can enhance mental health, but its effects on Alzheimer Disease (AD) remains unknown. To address the issue, 147 AD patients were randomly assigned into control (without GO-game intervention), Short-time GO-Game Intervention (SGGI, 1 h daily) and Long-time GO-game Intervention (LGGI, 2 h daily) groups. After 6-month follow-up, the game reduced the mean score of Montgomery-Asberg Depression Rating Scales (MADRS) of 4.72 (95% CI, 0.69 to 9.12) and Hospital Anxiety and Depression Scale (HADS) of 1.75 (95% CI, 0.17-3.68), and increased the mean score of Global Assessment of Functioning (GAF) of 4.95 (95% CI, -1.37-9.18) and RAND-36 of 4.61 (95% CI, -2.75-11.32) (P < 0.05 via controls). A GO-game intervention improved 9 of 11 items of KICA-dep (Kimberley Indigenous Cognitive Assessment of Depression). Meanwhile, serum levels of brain derived neurotrophic factor (BDNF) were higher in SGGI and LGGI groups (24.02 ± 7.16 and 28.88 ± 4.12 ng/ml respectively, P = 0.051) than those in controls (17.28 ± 7.75 ng/ml) (P < 0.001). The serum levels of BDNF showed a negative relation with MADRS and a positive relation with RAND-36 (P < 0.01). A GO-game intervention ameliorates AD manifestations by up-regulating BDNF levels.

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References

Mormont E, Jamart J, Jacques D . Symptoms of depression and anxiety after the disclosure of the diagnosis of Alzheimer disease. J Geriatr Psychiatry Neurol. 2014; 27(4):231-6. DOI: 10.1177/0891988714532021. View

Goerlich K, Witteman J, Aleman A, Martens S . Hearing feelings: affective categorization of music and speech in alexithymia, an ERP study. PLoS One. 2011; 6(5):e19501. PMC: 3090419. DOI: 10.1371/journal.pone.0019501. View

Johnson J, Chang C, Brambati S, Migliaccio R, Gorno-Tempini M, Miller B . Music recognition in frontotemporal lobar degeneration and Alzheimer disease. Cogn Behav Neurol. 2011; 24(2):74-84. PMC: 3691095. DOI: 10.1097/WNN.0b013e31821de326. View

Koelkebeck K, Pedersen A, Suslow T, Kueppers K, Arolt V, Ohrmann P . Theory of Mind in first-episode schizophrenia patients: correlations with cognition and personality traits. Schizophr Res. 2010; 119(1-3):115-23. DOI: 10.1016/j.schres.2009.12.015. View

Psotta L, Rockahr C, Gruss M, Kirches E, Braun K, Lessmann V . Impact of an additional chronic BDNF reduction on learning performance in an Alzheimer mouse model. Front Behav Neurosci. 2015; 9:58. PMC: 4367180. DOI: 10.3389/fnbeh.2015.00058. View

Hamilton A, Zamponi G, Ferguson S . Glutamate receptors function as scaffolds for the regulation of β-amyloid and cellular prion protein signaling complexes. Mol Brain. 2015; 8:18. PMC: 4395978. DOI: 10.1186/s13041-015-0107-0. View

Lattanzi S, Viticchi G, Falsetti L, Buratti L, Luzzi S, Provinciali L . Visit-to-visit blood pressure variability in Alzheimer disease. Alzheimer Dis Assoc Disord. 2014; 28(4):347-51. DOI: 10.1097/WAD.0000000000000040. View

Villoslada P, Arrondo G, Sepulcre J, Alegre M, Artieda J . Memantine induces reversible neurologic impairment in patients with MS. Neurology. 2008; 72(19):1630-3. DOI: 10.1212/01.wnl.0000342388.73185.80. View

Wiscott R, Seifert L . Possible consequences of social drinking in the early stages of Alzheimer disease. Geriatr Nurs. 2001; 22(2):100-4; quiz 105. DOI: 10.1067/mgn.2001.115201. View

10.

Barlaam F, Descoins M, Bertrand O, Hasbroucq T, Vidal F, Assaiante C . Time-Frequency and ERP Analyses of EEG to Characterize Anticipatory Postural Adjustments in a Bimanual Load-Lifting Task. Front Hum Neurosci. 2012; 5:163. PMC: 3247012. DOI: 10.3389/fnhum.2011.00163. View

11.

Richieri R, Boyer L, Padovani R, Adida M, Colavolpe C, Mundler O . Equivalent brain SPECT perfusion changes underlying therapeutic efficiency in pharmacoresistant depression using either high-frequency left or low-frequency right prefrontal rTMS. Prog Neuropsychopharmacol Biol Psychiatry. 2012; 39(2):364-70. DOI: 10.1016/j.pnpbp.2012.07.012. View

12.

Provencher V, Bier N, Audet T, Gagnon L . [Long-term effect of a cognitive intervention on learning and participation in a significant leisure activity in early dementia of Alzheimer type: a case study]. Psychol Neuropsychiatr Vieil. 2009; 7(2):131-40. DOI: 10.1684/pnv.2009.0166. View

13.

Pradier C, Sakarovitch C, Le Duff F, Layese R, Metelkina A, Anthony S . The mini mental state examination at the time of Alzheimer's disease and related disorders diagnosis, according to age, education, gender and place of residence: a cross-sectional study among the French National Alzheimer database. PLoS One. 2014; 9(8):e103630. PMC: 4122367. DOI: 10.1371/journal.pone.0103630. View

14.

Dysken M, Sano M, Asthana S, Vertrees J, Pallaki M, Llorente M . Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA. 2014; 311(1):33-44. PMC: 4109898. DOI: 10.1001/jama.2013.282834. View

15.

Evans D, Morris M, Rajan K . Vitamin E, memantine, and Alzheimer disease. JAMA. 2014; 311(1):29-30. DOI: 10.1001/jama.2013.282835. View

16.

Fan D, Li J, Zheng B, Hua L, Zuo Z . Enriched Environment Attenuates Surgery-Induced Impairment of Learning, Memory, and Neurogenesis Possibly by Preserving BDNF Expression. Mol Neurobiol. 2014; 53(1):344-354. DOI: 10.1007/s12035-014-9013-1. View

17.

Chang C, Zhao Y, Lee C, Ganguli M . Smoking, death, and Alzheimer disease: a case of competing risks. Alzheimer Dis Assoc Disord. 2011; 26(4):300-6. PMC: 3321062. DOI: 10.1097/WAD.0b013e3182420b6e. View

18.

Ahn S, Choi N, Kim Y, Seong J, Shin J, Jung S . Drug persistency of cholinesterase inhibitors for patients with dementia of Alzheimer type in Korea. Arch Pharm Res. 2014; 38(6):1255-62. DOI: 10.1007/s12272-014-0500-8. View

19.

Xiao Q, Wang C, Li J, Hou Q, Li J, Ma J . Ginkgolide B protects hippocampal neurons from apoptosis induced by beta-amyloid 25-35 partly via up-regulation of brain-derived neurotrophic factor. Eur J Pharmacol. 2010; 647(1-3):48-54. DOI: 10.1016/j.ejphar.2010.08.002. View

20.

Inoue K, Meguro K, Akanuma K, Meguro M, Yamaguchi S, Fukuda H . Impaired memory and executive function associated with decreased medial temporal and prefrontal blood flow in Clinical Dementia Rating 0.5 status: the Osaki-Tajiri project. Psychogeriatrics. 2012; 12(1):27-33. DOI: 10.1111/j.1479-8301.2011.00384.x. View