The Impacts of a GO-game (Chinese Chess) Intervention on Alzheimer Disease in a Northeast Chinese Population
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A GO game can enhance mental health, but its effects on Alzheimer Disease (AD) remains unknown. To address the issue, 147 AD patients were randomly assigned into control (without GO-game intervention), Short-time GO-Game Intervention (SGGI, 1 h daily) and Long-time GO-game Intervention (LGGI, 2 h daily) groups. After 6-month follow-up, the game reduced the mean score of Montgomery-Asberg Depression Rating Scales (MADRS) of 4.72 (95% CI, 0.69 to 9.12) and Hospital Anxiety and Depression Scale (HADS) of 1.75 (95% CI, 0.17-3.68), and increased the mean score of Global Assessment of Functioning (GAF) of 4.95 (95% CI, -1.37-9.18) and RAND-36 of 4.61 (95% CI, -2.75-11.32) (P < 0.05 via controls). A GO-game intervention improved 9 of 11 items of KICA-dep (Kimberley Indigenous Cognitive Assessment of Depression). Meanwhile, serum levels of brain derived neurotrophic factor (BDNF) were higher in SGGI and LGGI groups (24.02 ± 7.16 and 28.88 ± 4.12 ng/ml respectively, P = 0.051) than those in controls (17.28 ± 7.75 ng/ml) (P < 0.001). The serum levels of BDNF showed a negative relation with MADRS and a positive relation with RAND-36 (P < 0.01). A GO-game intervention ameliorates AD manifestations by up-regulating BDNF levels.
Pensavalle C, Solinas M, Gardoni C, Giorgi G, Antognozzi T, Alessio F PLoS One. 2024; 19(2):e0298728.
PMID: 38422015 PMC: 10903794. DOI: 10.1371/journal.pone.0298728.
Olczak A, Truszczynska-Baszak A, Stepien A, Gorecki K Int J Environ Res Public Health. 2022; 19(18).
PMID: 36142042 PMC: 9517178. DOI: 10.3390/ijerph191811769.
Liang D, Qiu L, Duan X, Chen H, Liu C, Gong Q Front Neurosci. 2022; 16:877103.
PMID: 35712460 PMC: 9195868. DOI: 10.3389/fnins.2022.877103.
Iizuka A, Murayama H, Machida M, Amagasa S, Inoue S, Fujiwara T Front Aging Neurosci. 2021; 13:758562.
PMID: 34916923 PMC: 8669795. DOI: 10.3389/fnagi.2021.758562.
Du B, Lakshminarayanan M, Krishna M, Vaitheswaran S, Chandra M, Sivaraman S Psychogeriatrics. 2020; 21(2):220-238.
PMID: 33336529 PMC: 7986620. DOI: 10.1111/psyg.12647.