Impact of Alcohol Drinking on Gastric Cancer Development According to Helicobacter Pylori Infection Status

Overview

Journal Br J Cancer

Specialty Oncology

Date 2015 Sep 18

PMID 26379079

Citations 28

Authors

Seung-Hyun Ma

Woohyun Jung

Elisabete Weiderpass

Jieun Jang

Yunji Hwang

Chunghyun Ahn

Kwang-Pil Ko

Soung-Hoon Chang

Hai-Rim Shin

Keun-Young Yoo

Sue K Park

Affiliations

Soon will be listed here.

Abstract

Background: Helicobacter pylori are major carcinogen of gastric cancer, but the associations among gastric cancer, H. pylori infection status, and alcohol consumption are not fully described. This study aimed to clarify how H. pylori infection status affects the association between alcohol consumption and gastric cancer risk.

Methods: We selected 949 case-cohort participants from the 18,863 Korean Multi-center Cancer Cohort (KMCC) populations. Gastric cancer incidence inside and outside of the subcohort were 12 and 254 cases, respectively. Seropositivities for CagA, VacA, and H. pylori infection were determined by performing immunoblot assays. Weighted Cox regression models were used to calculate hazard ratios and 95% confidence intervals (CIs).

Results: Relative to non-drinking, heavy drinking (⩾7 times a week), and binge drinking (⩾55 g alcohol intake per occasion) showed a 3.48-fold (95% CI, 1.13-10.73) and 3.27-fold (95% CI, 1.01-10.56) higher risk in subjects not previously infected by H. pylori. There was no significant association between drinking pattern and gastric cancer risk in H. pylori IgG seropositive subjects. An increased risk for gastric cancer in heavy- and binge-drinking subjects were also present in subjects not infected by CagA- or VacA-secreting H. pylori.

Conclusions: Heavy and binge alcohol consumption is an important risk factor related to an increasing incidence of gastric cancer in a population not infected by H. pylori.

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