Using Human Genetics to Make New Medicines

Overview

Journal Nat Rev Genet

Specialty Genetics

Date 2015 Sep 16

PMID 26370900

Citations 17

Authors

Jeffrey C Barrett

Ian Dunham

Ewan Birney

Affiliations

Soon will be listed here.

Abstract

Jeffrey Barrett, Ian Dunham and Ewan Birney discuss the initiatives of the newly founded Centre for Therapeutic Target Validation, including a range of approaches to use human genetics to inform drug discovery and make better medicines.

Citing Articles

Genetic factors associated with reasons for clinical trial stoppage.

Razuvayevskaya O, Lopez I, Dunham I, Ochoa D Nat Genet. 2024; 56(9):1862-1867.

PMID: 39075208 PMC: 11387188. DOI: 10.1038/s41588-024-01854-z.

Perspective of the GEMSTONE Consortium on Current and Future Approaches to Functional Validation for Skeletal Genetic Disease Using Cellular, Molecular and Animal-Modeling Techniques.

Rauner M, Foessl I, Formosa M, Kague E, Prijatelj V, Lopez N Front Endocrinol (Lausanne). 2021; 12:731217.

PMID: 34938269 PMC: 8686830. DOI: 10.3389/fendo.2021.731217.

GW-SEM 2.0: Efficient, Flexible, and Accessible Multivariate GWAS.

Pritikin J, Neale M, Prom-Wormley E, Clark S, Verhulst B Behav Genet. 2021; 51(3):343-357.

PMID: 33604756 DOI: 10.1007/s10519-021-10043-1.

The Musculoskeletal Knowledge Portal: Making Omics Data Useful to the Broader Scientific Community.

Kiel D, Kemp J, Rivadeneira F, Westendorf J, Karasik D, Duncan E J Bone Miner Res. 2020; 35(9):1626-1633.

PMID: 32777102 PMC: 8114232. DOI: 10.1002/jbmr.4147.

Precision and Personalized Medicine: How Genomic Approach Improves the Management of Cardiovascular and Neurodegenerative Disease.

Strianese O, Rizzo F, Ciccarelli M, Galasso G, DAgostino Y, Salvati A Genes (Basel). 2020; 11(7).

PMID: 32640513 PMC: 7397223. DOI: 10.3390/genes11070747.

References

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