Wnt3a: Functions and Implications in Cancer

Overview

Journal Chin J Cancer

Publisher Biomed Central

Specialty Oncology

Date 2015 Sep 16

PMID 26369691

Citations 46

Authors

Sha He

Yi Lu

Xia Liu

Xin Huang

Evan T Keller

Chao-Nan Qian

Jian Zhang

Affiliations

Soon will be listed here.

Abstract

Wnt3a, one of Wnt family members, plays key roles in regulating pleiotropic cellular functions, including self-renewal, proliferation, differentiation, and motility. Accumulating evidence has suggested that Wnt3a promotes or suppresses tumor progression via the canonical Wnt signaling pathway depending on cancer type. In addition, the roles of Wnt3a signaling can be inhibited by multiple proteins or chemicals. Herein, we summarize the latest findings on Wnt3a as an important therapeutic target in cancer.

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