Ocular Motor Signatures of Cognitive Dysfunction in Multiple Sclerosis

Overview

Journal Nat Rev Neurol

Specialty Neurology

Date 2015 Sep 16

PMID 26369516

Citations 12

Authors

Joanne Fielding

Meaghan Clough

Shin Beh

Lynette Millist

Derek Sears

Ashley N Frohman

Nathaniel Lizak

Jayne Lim

Scott Kolbe

Robert L Rennaker 2nd

Teresa C Frohman

Owen B White

Elliot M Frohman

Affiliations

Soon will be listed here.

Abstract

The anatomical and functional overlap between ocular motor command circuitry and the higher-order networks that form the scaffolding for cognition makes for a compelling hypothesis that measures of ocular motility could provide a means to sensitively interrogate cognitive dysfunction in people with multiple sclerosis (MS). Such an approach may ultimately provide objective and reproducible measures of cognitive dysfunction that offer an innovative capability to refine diagnosis, improve prognostication, and more accurately codify disease burden. A further dividend may be the validation and application of biomarkers that can be used in studies aimed at identifying and monitoring preventative, protective and even restorative properties of novel neurotherapeutics in MS. This Review discusses the utility of ocular motor measures in patients with MS to characterize disruption to wide-ranging networks that support cognitive function.

Citing Articles

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