Dynamic Microglial Modulation of Spatial Learning and Social Behavior

Overview

Journal Brain Behav Immun

Publisher Elsevier

Specialties Allergy & Immunology
Neurology
Psychiatry

Date 2015 Sep 9

PMID 26348580

Citations 62

Authors

Luisa Torres

Joan Danver

Kyungmin Ji

Jeremy T Miyauchi

Danling Chen

Maria E Anderson

Brian L West

John K Robinson

Stella E Tsirka

Affiliations

Soon will be listed here.

Abstract

Microglia are active players in inflammation, but also have important supporting roles in CNS maintenance and function, including modulation of neuronal activity. We previously observed an increase in the frequency of excitatory postsynaptic current in organotypic brain slices after depletion of microglia using clodronate. Here, we describe that local hippocampal depletion of microglia by clodronate alters performance in tests of spatial memory and sociability. Global depletion of microglia by high-dose oral administration of a Csf1R inhibitor transiently altered spatial memory but produced no change in sociability behavior. Microglia depletion and behavior effects were both reversible, consistent with a dynamic role for microglia in the regulation of such behaviors.

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