Diagnostic Accuracy of a Short Endoscopic Secretin Test in Patients With Cystic Fibrosis

Overview

Journal Pancreas

Specialty Gastroenterology

Date 2015 Sep 9

PMID 26348465

Citations 5

Authors

Trond Engjom

Friedemann Erchinger

Birger Norderud Laerum

Erling Tjora

Lage Aksnes

Odd Helge Gilja

Georg Dimcevski

Affiliations

Soon will be listed here.

Abstract

Objective: Short endoscopic secretin tests for exocrine pancreatic function are not properly evaluated in cystic fibrosis (CF).

Methods: Patients with CF and healthy controls (HCs) underwent endoscopic collection of duodenal juice between 30 and 45 minutes after secretin stimulation. Duodenal juice was analyzed for HCO3 concentration and pancreatic enzyme activities. Stool was analyzed for fecal elastase.

Results: Thirty-one patients with CF and 25 HCs were tested. Patients were classified as exocrine pancreatic sufficient (n = 13) or insufficient (n = 18). Both bicarbonate concentrations and enzyme activities in duodenal juice differentiated patients with CFI from patients with CFS and HC (P < 0.001). The population displays strong correlation between severe CF genotype in both alleles and pancreatic insufficient phenotype (P < 0.001).

Conclusions: Pancreatic exocrine insufficient CF patients could be differentiated from exocrine sufficient patients and HCs using short endoscopic secretin test.

Citing Articles

A Review of Exocrine Pancreatic Insufficiency in Children beyond Cystic Fibrosis and the Role of Endoscopic Direct Pancreatic Function Testing.

Pandey A, Mehta D, Horvath K Curr Gastroenterol Rep. 2025; 27(1):14.

PMID: 39971805 DOI: 10.1007/s11894-025-00959-7.

Assessment of exocrine pancreatic function in children and adolescents with direct and indirect testing.

Hopson P, Smadi Y, Mehta V, Patel S, Mehta D, Horvath K Front Pediatr. 2022; 10:908542.

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Assessing the impact of cystic fibrosis on the antipyretic response of ibuprofen in children: Physiologically-based modeling as a candle in the dark.

Cicali B, Long T, Kim S, Cristofoletti R Br J Clin Pharmacol. 2020; 86(11):2247-2255.

PMID: 32335930 PMC: 7576628. DOI: 10.1111/bcp.14326.

Sonographic pancreas echogenicity in cystic fibrosis compared to exocrine pancreatic function and pancreas fat content at Dixon-MRI.

Engjom T, Kavaliauskiene G, Tjora E, Erchinger F, Wathle G, Laerum B PLoS One. 2018; 13(7):e0201019.

PMID: 30048483 PMC: 6062060. DOI: 10.1371/journal.pone.0201019.

Contrast-enhanced ultrasonography of the pancreas shows impaired perfusion in pancreas insufficient cystic fibrosis patients.

Engjom T, Nylund K, Erchinger F, Stangeland M, Laerum B, Mezl M BMC Med Imaging. 2018; 18(1):14.

PMID: 29764411 PMC: 5952595. DOI: 10.1186/s12880-018-0259-3.

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