The Use and Effectiveness of Triple Multiplex System for Coding Region Single Nucleotide Polymorphism in Mitochondrial DNA Typing of Archaeologically Obtained Human Skeletons from Premodern Joseon Tombs of Korea

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Sep 9

PMID 26345190

Citations 1

Authors

Chang Seok Oh

Soong Deok Lee

Yi-Suk Kim

Dong Hoon Shin

Affiliations

Soon will be listed here.

Abstract

Previous study showed that East Asian mtDNA haplogroups, especially those of Koreans, could be successfully assigned by the coupled use of analyses on coding region SNP markers and control region mutation motifs. In this study, we tried to see if the same triple multiplex analysis for coding regions SNPs could be also applicable to ancient samples from East Asia as the complementation for sequence analysis of mtDNA control region. By the study on Joseon skeleton samples, we know that mtDNA haplogroup determined by coding region SNP markers successfully falls within the same haplogroup that sequence analysis on control region can assign. Considering that ancient samples in previous studies make no small number of errors in control region mtDNA sequencing, coding region SNP analysis can be used as good complimentary to the conventional haplogroup determination, especially of archaeological human bone samples buried underground over long periods.

Citing Articles

Paleogenetic study on the 17th century Korean mummy with atherosclerotic cardiovascular disease.

Shin D, Oh C, Hong J, Kim Y, Lee S, Lee E PLoS One. 2017; 12(8):e0183098.

PMID: 28813480 PMC: 5559090. DOI: 10.1371/journal.pone.0183098.

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