The Role of MicroRNAs in Enteroviral Infections

Overview

Journal Braz J Infect Dis

Specialty Infectious Diseases

Date 2015 Sep 7

PMID 26342975

Citations 11

Authors

Jing Wu

Li Shen

Jianguo Chen

Huaxi Xu

Lingxiang Mao

Affiliations

Soon will be listed here.

Abstract

The genus Enterovirus, a member of the Picornavirus family, are RNA viruses that can cause poliomyelitis, hand-food-mouth disease, viral meningitis or meningoencephalitis, viral myocarditis and so on. MicroRNAs are a class of highly conserved, small noncoding RNAs recognized as important regulators of gene expression. Recent studies found that MicroRNAs play a significant role in the infection of Enterovirus, such as enterovirus 71, coxsackievirus B3 and other Enterovirus. Enteroviral infection can alter the expression of cellular MicroRNAs, and cellular MicroRNAs can modulate viral pathogenesis and replication by regulating the expression level of viral or host's genes. Herein, this review summarizes the role of MicroRNAs in enteroviral infection.

Citing Articles

MicroRNAs in Myocarditis-Review of the Preclinical In Vivo Trials.

Procyk G, Grodzka O, Procyk M, Gasecka A, Gluszek K, Wrzosek M Biomedicines. 2023; 11(10).

PMID: 37893097 PMC: 10604573. DOI: 10.3390/biomedicines11102723.

The role of miRNAs in viral myocarditis, and its possible implication in induction of mRNA-based COVID-19 vaccines-induced myocarditis.

AbdelMassih A, Agha H, El-Saiedi S, El-Sisi A, Shershaby M, Gaber H Bull Natl Res Cent. 2022; 46(1):267.

PMID: 36415483 PMC: 9672617. DOI: 10.1186/s42269-022-00955-1.

Implication of microRNA as a potential biomarker of myocarditis.

Oh J, Kim G, Seok H Clin Exp Pediatr. 2022; 65(5):230-238.

PMID: 35240034 PMC: 9082251. DOI: 10.3345/cep.2021.01802.

MiR-146a down-regulates inflammatory response by targeting TLR3 and TRAF6 in Coxsackievirus B infection.

Fei Y, Chaulagain A, Wang T, Chen Y, Liu J, Yi M RNA. 2019; 26(1):91-100.

PMID: 31676570 PMC: 6913124. DOI: 10.1261/rna.071985.119.

Host MicroRNA hsa-miR-494-3p Promotes EV71 Replication by Directly Targeting PTEN.

Zhao Q, Xiong Y, Xu J, Chen S, Li P, Huang Y Front Cell Infect Microbiol. 2018; 8:278.

PMID: 30234021 PMC: 6130220. DOI: 10.3389/fcimb.2018.00278.

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