Phenotypic and Imaging Features of FLNA-negative Patients with Bilateral Periventricular Nodular Heterotopia and Epilepsy

Overview

Journal Epilepsy Behav

Specialties Neurology
Psychology
Social Sciences

Date 2015 Sep 5

PMID 26340046

Citations 5

Authors

Zianka Fallil

Heath Pardoe

Robert Bachman

Benjamin Cunningham

Isha Parulkar

Catherine Shain

Annapurna Poduri

Robert Knowlton

Ruben Kuzniecky

Affiliations

Soon will be listed here.

Abstract

Purpose: Periventricular nodular heterotopia (PVNH) is a malformation of cortical development due to impaired neuronal migration resulting in the formation of nodular masses of neurons and glial cells in close proximity to the ventricular walls. We report the clinical characteristics of the largest case series of FLNA-negative patients with seizures and bilateral periventricular heterotopia.

Methods: Participants were recruited through the Epilepsy Phenome/Genome Project (EPGP), a multicenter collaborative effort to collect detailed phenotypic data and DNA on a large number of individuals with epilepsy, including a cohort with symptomatic epilepsy related to PVNH. Included subjects had epilepsy, and MRI confirmed bilateral PVNH. Magnetic resonance imaging studies were visually and quantitatively reviewed to investigate the topographic extent of PVNH, symmetry, and laterality.

Key Findings: We analyzed data on 71 patients with bilateral PVNH. The incidence of febrile seizures was 16.6%. There was at least one other family member with epilepsy in 36.9% of this population. Developmental delay was present in 21.8%. Focal onset seizures were the most common type of seizure presentation (79.3%). High heterotopia burden was strongly associated with female gender and trigonal nodular localization. There was no evidence for differences in brain volume between PVNH subjects and controls. No relationship was observed between heterotopic volume and gender, developmental delay, location of PVNH, ventricular or cerebellar abnormalities, laterality of seizure onset, age at seizure onset, and duration of epilepsy.

Significance: A direct correlation was observed between high heterotopia burden, female gender, and trigonal location in this large cohort of FLNA-negative bilateral PVNH patients with epilepsy. Quantitative MRI measurements indicated that this correlation is based on the diffuse nature of the heterotopic nodules rather than on the total volume of abnormal heterotopic tissue.

Citing Articles

Periventricular nodular heterotopias is associated with mutation at the FLNA locus-a case history and a literature review.

Yang L, Wu G, Yin H, Pan M, Zhu Y BMC Pediatr. 2023; 23(1):346.

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The clinical and imaging features of FLNA positive and negative periventricular nodular heterotopia.

Lu Y, Hsu C, Liu Y, Chan C, Chuang Y, Lin C Biomed J. 2022; 45(3):542-548.

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Size of Subcortical Band Heterotopia Influences the Susceptibility to Hyperthermia-Induced Seizures in a Rat Model.

Moustaki K, Buhler E, Martinez R, Watrin F, Represa A, Manent J Front Cell Neurosci. 2019; 13:473.

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De novo and inherited private variants in MAP1B in periventricular nodular heterotopia.

Heinzen E, ONeill A, Zhu X, Allen A, Bahlo M, Chelly J PLoS Genet. 2018; 14(5):e1007281.

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