TEL2 Suppresses Metastasis by Down-regulating SERPINE1 in Nasopharyngeal Carcinoma

Overview

Journal Oncotarget

Specialty Oncology

Date 2015 Sep 4

PMID 26335051

Citations 29

Authors

Yi Sang

Ming-Yuan Chen

Donghua Luo

Ru-Hua Zhang

Li Wang

Mei Li

Rongzhen Luo

Chao-Nan Qian

Jian-Yong Shao

Yi-Xin Zeng

Tiebang Kang

Affiliations

Soon will be listed here.

Abstract

Metastasis is the major cause of treatment failure in patients with nasopharyngeal carcinoma (NPC). However, the molecular mechanisms of NPC metastasis are poorly understood. Here, using our customized gene microarray containing all of the known human transcription factors and the current markers for epithelial-mesenchymal transition, we report that TEL2 was down-regulated in highly metastatic NPC cells and the metastatic tissues in lymph node. Mechanistically, TEL2 inhibits the cell migration and invasion in vitro and metastasis in vivo by directly suppressing the SERPINE1 promoter in NPC. Consistently, an inverse correlation was observed between the protein levels of TEL2 and SERPINE1 using clinical NPC samples. Collectively, we have provided the first evidence that TEL2 plays a key role in NPC metastasis by directly down-regulating SERPINE1, and that this novel axis of TEL2 / SERPINE1 may be valuable to develop new strategies for treating NPC patients with metastasis.

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