Brief Report: Effects of Tenofovir and Amphotericin B Deoxycholate Coadministration on Kidney Function in Patients Treated for Cryptococcal Meningitis

Overview

Journal J Acquir Immune Defic Syndr

Specialty Infectious Diseases

Date 2015 Sep 4

PMID 26334743

Citations 2

Authors

Reuben Kiggundu

Bozena M Morawski

Nathan C Bahr

Joshua Rhein

Abdu K Musubire

Darlisha A Williams

Mahsa Abassi

Henry W Nabeta

Kathy H Hullsiek

David B Meya

David R Boulware

Affiliations

Soon will be listed here.

Abstract

The effect of tenofovir and amphotericin coadministration on kidney function is poorly characterized. We measured creatinine during induction therapy and at 4 weeks after diagnosis in Ugandans undergoing cryptococcal meningitis therapy and classified as not receiving antiretroviral therapy (ART), receiving nontenofovir ART or receiving tenofovir-based ART. Longitudinal creatinine changes and grade 2-4 creatinine adverse events were evaluated across groups. Creatinine concentrations were similar across ART groups. At 4 weeks after diagnosis, creatinine was 0.25 mg/dL higher than at diagnosis, but similar across groups. Adverse event incidence was also similar across ART groups. Tenofovir and amphotericin coadministration did not increase the risk of kidney dysfunction.

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References

Walsh T, Finberg R, Arndt C, Hiemenz J, Schwartz C, Bodensteiner D . Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group. N Engl J Med. 1999; 340(10):764-71. DOI: 10.1056/NEJM199903113401004. View

Yano T, Itoh Y, Kawamura E, Maeda A, Egashira N, Nishida M . Amphotericin B-induced renal tubular cell injury is mediated by Na+ Influx through ion-permeable pores and subsequent activation of mitogen-activated protein kinases and elevation of intracellular Ca2+ concentration. Antimicrob Agents Chemother. 2009; 53(4):1420-6. PMC: 2663073. DOI: 10.1128/AAC.01137-08. View

Matsushita K, Mahmoodi B, Woodward M, Emberson J, Jafar T, Jee S . Comparison of risk prediction using the CKD-EPI equation and the MDRD study equation for estimated glomerular filtration rate. JAMA. 2012; 307(18):1941-51. PMC: 3837430. DOI: 10.1001/jama.2012.3954. View

Luber A, Maa L, Lam M, Guglielmo B . Risk factors for amphotericin B-induced nephrotoxicity. J Antimicrob Chemother. 2001; 43(2):267-71. DOI: 10.1093/jac/43.2.267. View

Jarvis J, Bicanic T, Loyse A, Namarika D, Jackson A, Nussbaum J . Determinants of mortality in a combined cohort of 501 patients with HIV-associated Cryptococcal meningitis: implications for improving outcomes. Clin Infect Dis. 2013; 58(5):736-45. PMC: 3922213. DOI: 10.1093/cid/cit794. View

Deray G . Amphotericin B nephrotoxicity. J Antimicrob Chemother. 2002; 49 Suppl 1:37-41. DOI: 10.1093/jac/49.suppl_1.37. View

Trejtnar F, Mandikova J, Kocincova J, Volkova M . Renal handling of amphotericin B and amphotericin B-deoxycholate and potential renal drug-drug interactions with selected antivirals. Antimicrob Agents Chemother. 2014; 58(10):5650-7. PMC: 4187917. DOI: 10.1128/AAC.02829-14. View

Levey A, Stevens L, Schmid C, Zhang Y, Castro 3rd A, Feldman H . A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009; 150(9):604-12. PMC: 2763564. DOI: 10.7326/0003-4819-150-9-200905050-00006. View

Aberg J, Gallant J, Ghanem K, Emmanuel P, Zingman B, Horberg M . Primary care guidelines for the management of persons infected with HIV: 2013 update by the HIV medicine association of the Infectious Diseases Society of America. Clin Infect Dis. 2013; 58(1):e1-34. DOI: 10.1093/cid/cit665. View

10.

Jose S, Hamzah L, Campbell L, Hill T, Fisher M, Leen C . Incomplete reversibility of estimated glomerular filtration rate decline following tenofovir disoproxil fumarate exposure. J Infect Dis. 2014; 210(3):363-73. PMC: 4091582. DOI: 10.1093/infdis/jiu107. View

11.

Durski K, M Kuntz K, Yasukawa K, Virnig B, Meya D, Boulware D . Cost-effective diagnostic checklists for meningitis in resource-limited settings. J Acquir Immune Defic Syndr. 2013; 63(3):e101-8. PMC: 3683123. DOI: 10.1097/QAI.0b013e31828e1e56. View

12.

Day J, Chau T, Wolbers M, Mai P, Dung N, Mai N . Combination antifungal therapy for cryptococcal meningitis. N Engl J Med. 2013; 368(14):1291-1302. PMC: 3978204. DOI: 10.1056/NEJMoa1110404. View

13.

Chaisiri K, Bowonwatanuwong C, Kasettratat N, Kiertiburanakul S . Incidence and risk factors for tenofovir-associated renal function decline among Thai HIV-infected patients with low-body weight. Curr HIV Res. 2010; 8(7):504-9. DOI: 10.2174/157016210793499259. View

14.

Boulware D, Meya D, Muzoora C, Rolfes M, Hullsiek K, Musubire A . Timing of antiretroviral therapy after diagnosis of cryptococcal meningitis. N Engl J Med. 2014; 370(26):2487-98. PMC: 4127879. DOI: 10.1056/NEJMoa1312884. View

15.

Bahr N, Rolfes M, Musubire A, Nabeta H, Williams D, Rhein J . Standardized electrolyte supplementation and fluid management improves survival during amphotericin therapy for cryptococcal meningitis in resource-limited settings. Open Forum Infect Dis. 2015; 1(2):ofu070. PMC: 4281785. DOI: 10.1093/ofid/ofu070. View

16.

Fernandez-Fernandez B, Montoya-Ferrer A, Sanz A, Sanchez-Nino M, Izquierdo M, Poveda J . Tenofovir nephrotoxicity: 2011 update. AIDS Res Treat. 2011; 2011:354908. PMC: 3119412. DOI: 10.1155/2011/354908. View

17.

Wingard J, Kubilis P, Lee L, Yee G, White M, Walshe L . Clinical significance of nephrotoxicity in patients treated with amphotericin B for suspected or proven aspergillosis. Clin Infect Dis. 1999; 29(6):1402-7. DOI: 10.1086/313498. View

18.

Jarvis J, Meintjes G, Williams A, Brown Y, Crede T, Harrison T . Adult meningitis in a setting of high HIV and TB prevalence: findings from 4961 suspected cases. BMC Infect Dis. 2010; 10:67. PMC: 3161361. DOI: 10.1186/1471-2334-10-67. View

19.

Mayer J, Doubek M, Doubek J, Horky D, Scheer P, STEPANEK M . Reduced nephrotoxicity of conventional amphotericin B therapy after minimal nephroprotective measures: animal experiments and clinical study. J Infect Dis. 2002; 186(3):379-88. DOI: 10.1086/341662. View

20.

Sawaya B, Weihprecht H, Campbell W, Lorenz J, Webb R, Briggs J . Direct vasoconstriction as a possible cause for amphotericin B-induced nephrotoxicity in rats. J Clin Invest. 1991; 87(6):2097-107. PMC: 296966. DOI: 10.1172/JCI115240. View