Engineered Biomaterials for Development of Nucleic Acid Vaccines

Overview

Journal Biomater Res

Specialty Biomedical Engineering

Date 2015 Sep 3

PMID 26331076

Citations 8

Authors

Jun Yang

Yan Li

Shubin Jin

Jing Xu

Paul C Wang

Xing-Jie Liang

Xin Zhang

Affiliations

Soon will be listed here.

Abstract

Nucleic acid vaccines have attracted many attentions since they have presented some superiority over traditional vaccines. However, they could only induce moderate immunogenicity. The route and formulation of nucleic acid vaccines have strong effects on the immune response and efficiency. Numerous biomaterials are used as a tool to enhance the immunogenicity of antigens. They deliver the antigens into the cells through particle- and non-particle-mediated pathway. However, challenges remain due to lack of comprehensive understanding of the actions of these biomaterials as a carrier/adjuvant. Herein, this review focuses on the evolution of biomaterials used for nucleic acid vaccines, discusses the advantages and disadvantages for gene delivery and immunostimulation of variety of structures of the biomaterials, in order to provide new thought on rational design of carrier/adjuvant and better understanding of mechanism of action in both immunostimulatory and delivery methods.

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