Adenomyosis and Its Impact on Women Fertility

Overview

Journal Iran J Reprod Med

Specialty Reproductive Medicine

Date 2015 Sep 3

PMID 26330846

Citations 11

Authors

Elisabetta Garavaglia

Serafini Audrey

Inversetti Annalisa

Ferrari Stefano

Tandoi Iacopo

Corti Laura

Candiani Massimo

Affiliations

Soon will be listed here.

Abstract

Adenomyosis is a widespread disease affecting the reproductive period of women's life. In the last ten years, different pathogenetic hypotheses have been proposed to explain the initiation and development of the disease. This article aims to present and discuss the most important pathophysiologic mechanisms underlying adenomyosis development in order to clarify the relationship between adenomyosis and infertility. A PubMed search was undertaken for English language literature using the MeSH terms 'adenomyosis', 'infertility', 'treatment', and 'pathogenesis'. Although the exact etiology of adenomyosis is unknown, many theories have been proposed. We analysed the most important pathogenic theories expressed and evaluated the potential consequences on women fertility. A better comprehension of the adenomyosis pathogenesis has allowed realizing that adenomyosis may affect young women and may have a great impact on their fertility through different mechanisms. The understanding of these mechanisms helps to clarify the potential usefulness of current therapies.

Citing Articles

Functional Implications of Estrogen and Progesterone Receptors Expression in Adenomyosis, Potential Targets for Endocrinological Therapy.

Sztachelska M, Ponikwicka-Tyszko D, Martinez-Rodrigo L, Bernaczyk P, Palak E, Polchlopek W J Clin Med. 2022; 11(15).

PMID: 35956024 PMC: 9369051. DOI: 10.3390/jcm11154407.

Is there a relationship between adenomyosis and nabothian cyst?.

Yilmaz P, Kadiyoran C, Horasanli J Pol J Radiol. 2022; 87:e281-e285.

PMID: 35774217 PMC: 9215300. DOI: 10.5114/pjr.2022.116913.

The Potential Relationship Between Environmental Endocrine Disruptor Exposure and the Development of Endometriosis and Adenomyosis.

Stephens V, Rumph J, Ameli S, Bruner-Tran K, Osteen K Front Physiol. 2022; 12:807685.

PMID: 35153815 PMC: 8832054. DOI: 10.3389/fphys.2021.807685.

The Role of Abnormal Uterine Junction Zone in the Occurrence and Development of Adenomyosis.

Xie T, Xu X, Yang Y, Wu C, Liu X, Zhou L Reprod Sci. 2021; 29(10):2719-2730.

PMID: 34515984 DOI: 10.1007/s43032-021-00684-2.

Adenomyosis and Infertility-Review of Medical and Surgical Approaches.

Szubert M, Kozirog E, Olszak O, Krygier-Kurz K, Kazmierczak J, Wilczynski J Int J Environ Res Public Health. 2021; 18(3).

PMID: 33573117 PMC: 7908401. DOI: 10.3390/ijerph18031235.

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