Human Umbilical Cord Blood Stem Cells and Brain-derived Neurotrophic Factor for Optic Nerve Injury: a Biomechanical Evaluation

Overview

Journal Neural Regen Res

Date 2015 Sep 3

PMID 26330839

Citations 8

Authors

Zhong-Jun Zhang

Ya-Jun Li

Xiao-Guang Liu

Feng-Xiao Huang

Tie-Jun Liu

Dong-Mei Jiang

Xue-Man Lv

Min Luo

Affiliations

Soon will be listed here.

Abstract

Treatment for optic nerve injury by brain-derived neurotrophic factor or the transplantation of human umbilical cord blood stem cells has gained progress, but analysis by biomechanical indicators is rare. Rabbit models of optic nerve injury were established by a clamp. At 7 days after injury, the vitreous body received a one-time injection of 50 μg brain-derived neurotrophic factor or 1 × 10(6) human umbilical cord blood stem cells. After 30 days, the maximum load, maximum stress, maximum strain, elastic limit load, elastic limit stress, and elastic limit strain had clearly improved in rabbit models of optical nerve injury after treatment with brain-derived neurotrophic factor or human umbilical cord blood stem cells. The damage to the ultrastructure of the optic nerve had also been reduced. These findings suggest that human umbilical cord blood stem cells and brain-derived neurotrophic factor effectively repair the injured optical nerve, improve biomechanical properties, and contribute to the recovery after injury.

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