Two Birds with One Stone: Possible Dual-Role of Oxytocin in the Treatment of Diabetes and Osteoporosis

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2015 Sep 1

PMID 26322016

Citations 20

Authors

Seham Elabd

Ismail Sabry

Affiliations

Soon will be listed here.

Abstract

Oxytocin (OT), a hormone most commonly associated with labor and lactation, may have a wide variety of physiological and pathological functions, which makes OT and its receptor potential targets for drug therapy. In this review, we highlight the newly discovered metabolic role of OT in diabetes and its complication, such as diabetic osteopathy. OT may have positive metabolic effects; this is based on the change in glucose metabolism, lipid profile, and insulin sensitivity. It may modify glucose uptake and insulin sensitivity both through direct and indirect effects. It may also cause regenerative changes in diabetic pancreatic islet cells. Moreover, it has an anabolic effect on the bone biology. So, the activation of the OT receptor pathway by infusion of OT, OT analogs, or OT agonists may represent a promising approach for the treatment of diabetes and some of its complications, including diabetic osteopathy.

Citing Articles

A Modified Cell-Penetrating Peptide Enhances Insulin and Oxytocin Delivery across an RPMI 2650 Nasal Epithelial Cell Barrier In Vitro.

Wong S, Brown A, Abrahams A, Nurzak A, Eltaher H, Sykes D Pharmaceutics. 2024; 16(10).

PMID: 39458599 PMC: 11510563. DOI: 10.3390/pharmaceutics16101267.

identification and functional characterization of common genes associated with type 2 diabetes and hypertension.

Rabby M, Suzauddula M, Hasan M, Dewan M, Islam M Heliyon. 2024; 10(16):e36546.

PMID: 39262940 PMC: 11388505. DOI: 10.1016/j.heliyon.2024.e36546.

Mehdi S, Pusapati S, Khenhrani R, Farooqi M, Sarwar S, Alnasarat A Front Immunol. 2022; 13:864007.

PMID: 35572539 PMC: 9102389. DOI: 10.3389/fimmu.2022.864007.

Ameliorative Effect of Oxytocin on and Gene Expression, and Behavioral Patterns in Rats' Obesity-Induced Diabetes.

Elnagar A, El-Dawy K, El-Belbasi H, Rehan I, Embark H, Al-Amgad Z Front Public Health. 2022; 10:777129.

PMID: 35462799 PMC: 9021505. DOI: 10.3389/fpubh.2022.777129.

TRPV1, Nrf2, and COVID-19: Could Oxytocin Have a Beneficial Role to Play?.

Diep P Int Arch Allergy Immunol. 2022; 183(2):246-247.

PMID: 34979508 PMC: 8805070. DOI: 10.1159/000521246.

References

Maejima Y, Iwasaki Y, Yamahara Y, Kodaira M, Sedbazar U, Yada T . Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass. Aging (Albany NY). 2011; 3(12):1169-77. PMC: 3273897. DOI: 10.18632/aging.100408. View

Kendall D, Peters Harmel A . The metabolic syndrome, type 2 diabetes, and cardiovascular disease: understanding the role of insulin resistance. Am J Manag Care. 2003; 8(20 Suppl):S635-53; quiz S654-7. View

Danciu T, Adam R, Naruse K, Freeman M, Hauschka P . Calcium regulates the PI3K-Akt pathway in stretched osteoblasts. FEBS Lett. 2003; 536(1-3):193-7. DOI: 10.1016/s0014-5793(03)00055-3. View

Jankowski M, Bissonauth V, Gao L, Gangal M, Wang D, Danalache B . Anti-inflammatory effect of oxytocin in rat myocardial infarction. Basic Res Cardiol. 2009; 105(2):205-18. DOI: 10.1007/s00395-009-0076-5. View

Phaneuf S, Europe-Finner G, Varney M, MacKenzie I, Watson S, Lopez Bernal A . Oxytocin-stimulated phosphoinositide hydrolysis in human myometrial cells: involvement of pertussis toxin-sensitive and -insensitive G-proteins. J Endocrinol. 1993; 136(3):497-509. DOI: 10.1677/joe.0.1360497. View

Thomas T . The complex effects of leptin on bone metabolism through multiple pathways. Curr Opin Pharmacol. 2004; 4(3):295-300. DOI: 10.1016/j.coph.2004.01.009. View

Oshima K, Nampei A, Matsuda M, Iwaki M, Fukuhara A, Hashimoto J . Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun. 2005; 331(2):520-6. DOI: 10.1016/j.bbrc.2005.03.210. View

Tamma R, Colaianni G, Zhu L, DiBenedetto A, Greco G, Montemurro G . Oxytocin is an anabolic bone hormone. Proc Natl Acad Sci U S A. 2009; 106(17):7149-54. PMC: 2678458. DOI: 10.1073/pnas.0901890106. View

Szeto A, Nation D, Mendez A, Dominguez-Bendala J, Brooks L, Schneiderman N . Oxytocin attenuates NADPH-dependent superoxide activity and IL-6 secretion in macrophages and vascular cells. Am J Physiol Endocrinol Metab. 2008; 295(6):E1495-501. PMC: 2603556. DOI: 10.1152/ajpendo.90718.2008. View

10.

Guzzi F, Zanchetta D, Cassoni P, Guzzi V, Francolini M, Parenti M . Localization of the human oxytocin receptor in caveolin-1 enriched domains turns the receptor-mediated inhibition of cell growth into a proliferative response. Oncogene. 2002; 21(11):1658-67. DOI: 10.1038/sj.onc.1205219. View

11.

Tontonoz P, Hu E, Spiegelman B . Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell. 1994; 79(7):1147-56. DOI: 10.1016/0092-8674(94)90006-x. View

12.

Lippert T, Mueck A, Seeger H, Pfaff A . Effects of oxytocin outside pregnancy. Horm Res. 2003; 60(6):262-71. DOI: 10.1159/000074243. View

13.

Arletti R, Benelli A, Bertolini A . Oxytocin inhibits food and fluid intake in rats. Physiol Behav. 1990; 48(6):825-30. DOI: 10.1016/0031-9384(90)90234-u. View

14.

Di Benedetto A, Sun L, Zambonin C, Tamma R, Nico B, Calvano C . Osteoblast regulation via ligand-activated nuclear trafficking of the oxytocin receptor. Proc Natl Acad Sci U S A. 2014; 111(46):16502-7. PMC: 4246276. DOI: 10.1073/pnas.1419349111. View

15.

Elabd S, Sabry I, Hassan W, Nour H, Zaky K . Possible neuroendocrine role for oxytocin in bone remodeling. Endocr Regul. 2008; 41(4):131-41. View

16.

Koshimizu T, Nakamura K, Egashira N, Hiroyama M, Nonoguchi H, Tanoue A . Vasopressin V1a and V1b receptors: from molecules to physiological systems. Physiol Rev. 2012; 92(4):1813-64. DOI: 10.1152/physrev.00035.2011. View

17.

Bolanowski M, Halupczok J, Jawiarczyk-Przybylowska A . Pituitary disorders and osteoporosis. Int J Endocrinol. 2015; 2015:206853. PMC: 4383139. DOI: 10.1155/2015/206853. View

18.

Cnop M, Welsh N, Jonas J, Jorns A, Lenzen S, Eizirik D . Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes. 2005; 54 Suppl 2:S97-107. DOI: 10.2337/diabetes.54.suppl_2.s97. View

19.

Rouach V, Katzburg S, Koch Y, Stern N, Somjen D . Bone loss in ovariectomized rats: dominant role for estrogen but apparently not for FSH. J Cell Biochem. 2010; 112(1):128-37. DOI: 10.1002/jcb.22908. View

20.

Oda N, Imamura S, Fujita T, Uchida Y, Inagaki K, Kakizawa H . The ratio of leptin to adiponectin can be used as an index of insulin resistance. Metabolism. 2008; 57(2):268-73. DOI: 10.1016/j.metabol.2007.09.011. View