PDK1 Induces JunB, EMT, Cell Migration and Invasion in Human Gallbladder Cancer

Overview

Journal Oncotarget

Specialty Oncology

Date 2015 Aug 31

PMID 26318166

Citations 21

Authors

Shixian Lian

Yebo Shao

Houbao Liu

Junyi He

Weiqi Lu

Yong Zhang

Ying Jiang

Jun Zhu

Affiliations

Soon will be listed here.

Abstract

The protein 3-phosphoinositide-dependent protein kinase 1 (PDK1) is upregulated in cancer. Here we showed that PDK1 stimulated cell proliferation, invasion and metastasis in gallbladder cancer (GBC), by inducing JunB and epithelial-mesenchymal transition. JunB levels were increased in GBC samples and positively correlated with PDK1 levels in tumors. High levels of JunB predicted poor overall survival in GBC patients. Thus, PDK1 functions as a tumor promoter in human GBC by upregulating JunB.

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