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Triggerable Degradation of Polyurethanes for Tissue Engineering Applications

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Date 2015 Aug 28
PMID 26312436
Citations 17
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Abstract

Tissue engineered and bioactive scaffolds with different degradation rates are required for the regeneration of diverse tissues/organs. To optimize tissue regeneration in different tissues, it is desirable that the degradation rate of scaffolds can be manipulated to comply with various stages of tissue regeneration. Unfortunately, the degradation of most degradable polymers relies solely on passive controlled degradation mechanisms. To overcome this challenge, we report a new family of reduction-sensitive biodegradable elastomeric polyurethanes containing various amounts of disulfide bonds (PU-SS), in which degradation can be initiated and accelerated with the supplement of a biological product: antioxidant-glutathione (GSH). The polyurethanes can be processed into films and electrospun fibrous scaffolds. Synthesized materials exhibited robust mechanical properties and high elasticity. Accelerated degradation of the materials was observed in the presence of GSH, and the rate of such degradation depends on the amount of disulfide present in the polymer backbone. The polymers and their degradation products exhibited no apparent cell toxicity while the electrospun scaffolds supported fibroblast growth in vitro. The in vivo subcutaneous implantation model showed that the polymers prompt minimal inflammatory responses, and as anticipated, the polymer with the higher disulfide bond amount had faster degradation in vivo. This new family of polyurethanes offers tremendous potential for directed scaffold degradation to promote maximal tissue regeneration.

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References
1.
Heo D, Yang D, Lee J, Bae M, Kim J, Moon S . Burn-wound healing effect of gelatin/polyurethane nanofiber scaffold containing silver-sulfadiazine. J Biomed Nanotechnol. 2013; 9(3):511-5. DOI: 10.1166/jbn.2013.1509. View

2.
Adolph E, Pollins A, Cardwell N, Davidson J, Guelcher S, Nanney L . Biodegradable lysine-derived polyurethane scaffolds promote healing in a porcine full-thickness excisional wound model. J Biomater Sci Polym Ed. 2014; 25(17):1973-85. PMC: 4218871. DOI: 10.1080/09205063.2014.965997. View

3.
Ma Z, Hong Y, Nelson D, Pichamuthu J, Leeson C, Wagner W . Biodegradable polyurethane ureas with variable polyester or polycarbonate soft segments: effects of crystallinity, molecular weight, and composition on mechanical properties. Biomacromolecules. 2011; 12(9):3265-74. PMC: 3188984. DOI: 10.1021/bm2007218. View

4.
Vert M . Degradable and bioresorbable polymers in surgery and in pharmacology: beliefs and facts. J Mater Sci Mater Med. 2008; 20(2):437-46. DOI: 10.1007/s10856-008-3581-4. View

5.
Lomaestro B, Malone M . Glutathione in health and disease: pharmacotherapeutic issues. Ann Pharmacother. 1995; 29(12):1263-73. DOI: 10.1177/106002809502901213. View